Association of Improved Locoregional Control With Prolonged Survival in Early-Stage Extranodal Nasal-Type Natural Killer/T-Cell Lymphoma
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DOI: 10.1001/jamaoncol.2016.5094
Abstract: Importance The long-term survival benefit for radiotherapy (RT) in early-stage extranodal natural killer/T-cell lymphoma (NKTCL) is not known, and it is unclear whether improved locoregional control (LRC) translates into a survival benefit. Objective To investigate… read more here.
Keywords: stage extranodal; natural killer; early stage; dose ... See more keywords
Generation of universal natural killer cells from a cryopreserved cord blood mononuclear cell‐derived induced pluripotent stem cell library
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DOI: 10.1002/2211-5463.13460
Abstract: Natural killer (NK) cells play a key role in innate immunity and are regarded as a promising candidate for cellular immunotherapy. Natural killer cells may be generated from different sources, including induced pluripotent stem cells… read more here.
Keywords: cell; natural killer; killer cells; cord blood ... See more keywords
Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes.
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DOI: 10.1002/adma.201804395
Abstract: Recent advances in cancer immunotherapy have exploited the efficient potential of natural killer (NK) cells to kill tumor cells through antibody-dependent cell-mediated cytotoxicity (ADCC). However, this therapeutic strategy is seriously limited by tumor antigen heterogeneity… read more here.
Keywords: fragments antibodies; cell immunotherapy; natural killer; tumor ... See more keywords
Nanoscale Mechanosensing of Natural Killer Cells is Revealed by Antigen-Functionalized Nanowires.
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DOI: 10.1002/adma.201805954
Abstract: Cells sense their environment by transducing mechanical stimuli into biochemical signals. Commonly used tools to study cell mechanosensing provide limited spatial and force resolution. Here, a novel nanowire-based platform for monitoring cell forces is reported.… read more here.
Keywords: mechanosensing natural; natural killer; cells revealed; nanoscale mechanosensing ... See more keywords
Selenopeptide Nanomedicine Activates Natural Killer Cells for Enhanced Tumor Chemoimmunotherapy
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DOI: 10.1002/adma.202108167
Abstract: Chemoimmunotherapy using nanotechnology has shown great potential for cancer therapy in the clinic. However, uncontrolled transportation and synergistic responses remain challenges. Here, a self‐assembled selenopeptide nanoparticle that strengthens tumor chemoimmunotherapy through the activation of natural… read more here.
Keywords: tumor chemoimmunotherapy; natural killer; killer cells; chemoimmunotherapy ... See more keywords
Bioinspired Preservation of Natural Killer Cells for Cancer Immunotherapy
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DOI: 10.1002/advs.201802045
Abstract: Abstract The ability to cryopreserve natural killer (NK) cells has a significant potential in modern cancer immunotherapy. Current cryopreservation protocols cause deterioration in NK cell viability and functionality. This work reports the preservation of human… read more here.
Keywords: natural killer; preservation; cancer immunotherapy; cancer ... See more keywords
Natural killer cells: Innate immune system as a part of adaptive immunotherapy in hematological malignancies
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26529
Abstract: Natural killer (NK) cells are part of a phylogenetically old defense system, which is characterized by its strong cytolytic function against physiologically stressed cells such as tumor cells and virus‐infected cells. Their use in the… read more here.
Keywords: system; natural killer; killer cells; hematological malignancies ... See more keywords
A genomic‐augmented multivariate prognostic model for the survival of natural‐killer/T‐cell lymphoma patients from an international cohort
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DOI: 10.1002/ajh.26636
Abstract: With lowering costs of sequencing and genetic profiling techniques, genetic drivers can now be detected readily in tumors but current prognostic models for Natural‐killer/T cell lymphoma (NKTCL) have yet to fully leverage on them for… read more here.
Keywords: cell lymphoma; natural killer; killer cell;
Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors
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DOI: 10.1002/cac2.12394
Abstract: Natural killer (NK) cells are unique innate immune cells that mediate anti‐viral and anti‐tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell adoptive immunotherapy in humans has shown modest efficacy. In… read more here.
Keywords: natural killer; killer cells; immune checkpoints; solid tumors ... See more keywords
A novel prognostic model based on ferritin and nomogram‐revised risk index could better stratify patients with extranodal natural killer/T‐cell lymphoma
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DOI: 10.1002/cam4.5820
Abstract: Extranodal natural killer (NK)/T‐cell lymphoma (ENKTCL) is an aggressive lymphoma with marked heterogeneity, resulting in a distinct prognosis even in patients with the same disease stage. The nomogram‐revised risk index (NRI) has been proposed to… read more here.
Keywords: cell lymphoma; extranodal natural; natural killer; revised risk ... See more keywords
MOLECULAR CHARACTERIZATION OF EXTRANODAL NATURAL KILLER (NK)/T‐CELL LYMPHOMAS, NASAL TYPE FROM LATIN AMERICA
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DOI: 10.1002/hon.2437_115
Abstract: clinical trial is still ongoing (ClinicalTrials.gov, NCT 2085655). Furthermore, promising response of single agent, chidamide, a new oral HDAC inhibitor, for the treatment of relapsed or refractory NK/ TCL without significant EBV‐reactivation was recently observed… read more here.
Keywords: molecular characterization; killer cell; characterization extranodal; cell lymphomas ... See more keywords