Computer-aided identification of natural lead compounds as cyclooxygenase-2 inhibitors using virtual screening and molecular dynamic simulation
Sign Up to like & getrecommendations! Published in 2018 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.07.005
Abstract: In order to find more natural lead-compounds as inhibitors for Cyclooxygenase-2, the essential structural features for human cyclooxygenase-2 inhibitors and 3D-Quantitative structure activity relationship (3D-QSAR) model were carried out based on dataset from three confirmatory… read more here.
Keywords: cyclooxygenase inhibitors; lead compounds; aided identification; natural lead ... See more keywords
Natural Lead Levels in Dandelions ( Taraxacum officinale): A Weed, Folk Medicine, and Biomonitor.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental science & technology"
DOI: 10.1021/acs.est.8b04191
Abstract: The natural lead concentration of dandelion ( Taraxacum officinale) leaves is estimated to be 0.2 μg/g (dry weight), or 1-3 orders of magnitude below most contemporary measurements of that value for dandelions and other plants.… read more here.
Keywords: taraxacum officinale; medicine; lead levels; natural lead ... See more keywords
Synthesis of Bisphenol Neolignans Inspired by Honokiol as Antiproliferative Agents
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25030733
Abstract: Honokiol (2) is a natural bisphenol neolignan showing a variety of biological properties, including antitumor activity. Some studies pointed out 2 as a potential anticancer agent in view of its antiproliferative and pro-apoptotic activity towards… read more here.
Keywords: bisphenol; neolignans inspired; antiproliferative agents; bisphenol neolignans ... See more keywords
Genistein: A Potential Natural Lead Molecule for New Drug Design and Development for Treating Memory Impairment
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27010265
Abstract: Genistein is a naturally occurring polyphenolic molecule in the isoflavones group which is well known for its neuroprotection. In this review, we summarize the efficacy of genistein in attenuating the effects of memory impairment (MI)… read more here.
Keywords: design development; memory impairment; natural lead; potential natural ... See more keywords
Tilianin: A Potential Natural Lead Molecule for New Drug Design and Development for the Treatment of Cardiovascular Disorders
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030673
Abstract: Cardiovascular disorders (CVDs) are the leading risk factor for death worldwide, and research into the processes and treatment regimens has received a lot of attention. Tilianin is a flavonoid glycoside that can be found in… read more here.
Keywords: development; cardiovascular disorders; drug; natural lead ... See more keywords