The Natural Ligand for Metalloproteinase-A Multifaceted Drug Target
Sign Up to like & getrecommendations! Published in 2022 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-021-03778-4
Abstract: Metalloproteinase is one of the key components of Russell viper venom and it is the root cause of edema, blood coagulation, local tissue damage, hemorrhage, and inflammation during snakebite envenoming. Hence, finding a suitable metalloproteinase… read more here.
Keywords: metalloproteinase; multifaceted drug; metalloproteinase multifaceted; drug ... See more keywords
α-d-Galacturonic Acid as Natural Ligand for Selective Copper-Catalyzed N-Arylation of N-Containing Heterocycles
Sign Up to like & getrecommendations! Published in 2019 at "Synlett"
DOI: 10.1055/s-0039-1690226
Abstract: The first application of α-d-galacturonic acid hydrate (GalA) is reported here, as a potential O-donor ligand. The C–N couplings of N-heterocycles with aryl halides or arylboronic acids could be readily conducted and exhibited good functional… read more here.
Keywords: selective copper; natural ligand; acid natural; galacturonic acid ... See more keywords
Selected ideal natural ligand against TNBC by inhibiting CDC20, using bioinformatics and molecular biology.
Sign Up to like & getrecommendations! Published in 2021 at "Aging"
DOI: 10.18632/aging.203642
Abstract: OBJECT Find potential therapeutic targets of triple-negative breast cancer (TNBC) patients by bioinformatics. Screen ideal natural ligand that can bind with the potential target and inhibit it by using molecular biology. METHODS Bioinformatics and molecular… read more here.
Keywords: ideal natural; natural ligand; tnbc; biology ... See more keywords
Molecular dynamics identifies semi-rigid domains in the PD-1 checkpoint receptor bound to its natural ligand PD-L1
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.838129
Abstract: Cells in danger of being erroneously attacked by leucocytes express PD-L1 on their surface. These cells activate PD-1 on attacking leucocytes and send them to death, thus curbing erroneous, autoimmune attack. Unfortunately, cancer cells exploit… read more here.
Keywords: molecular dynamics; rigid domains; semi rigid; motion ... See more keywords
Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT
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DOI: 10.3390/ijms23042098
Abstract: Lipid transfer proteins (LTPs) are recognized as key players in the inter-organelle trafficking of lipids and are rapidly gaining attention as a novel molecular target for medicinal products. In mammalian cells, ceramide is newly synthesized… read more here.
Keywords: transport protein; natural ligand; transport; protein cert ... See more keywords