A strategy for the metabolomics-based screening of active constituents and quality consistency control for natural medicinal substance toad venom.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.05.054
Abstract: Natural medicinal substances (NMS) have great inconsistency due to chemical variability, seriously limiting their development as therapeutics. Here, we chose toad venom with anti-tumor activities as a model and developed a pipeline of metabolomics-based screening… read more here.
Keywords: toad venom; venom; control; natural medicinal ... See more keywords
One-pot derivatization for wide-scope detection of nucleobases and deoxyribosides in natural medicinal foods with liquid chromatography-tandem mass spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c03328
Abstract: A new chemical labeling-based LC-MS/MS approach was developed for quantitative profiling of nine canonical bases and deoxynucleosides (dNs) in natural products. Using 2-bromo-1-(4-dimethylamino-phenyl)-ethaone (BrDPE) as the tagging reagent, a previously unexploited N-alkylpyrimidine derivative (Nad) was… read more here.
Keywords: natural medicinal; detection; pot derivatization; one pot ... See more keywords
Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1037814
Abstract: Isoniazid (INH) and rifampicin (RFP) are the first-line medications for tuberculosis treatment, and liver injury is the major adverse effect. Natural medicinal ingredients provide distinct benefits in alleviating patients’ symptoms, lowering the liver injury risk,… read more here.
Keywords: medicinal ingredients; liver injury; rfp; induced liver ... See more keywords