Synthesis of 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A and their cytotoxic activity
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DOI: 10.1016/j.mencom.2017.01.026
Abstract: The herein synthesized 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A have lower cytotoxic activity towards the human lung adenocarcinoma A549 cell line compared to phaeosphaeride A. The presence of exocyclic C=C bond and N–OMe… read more here.
Keywords: methylphenyl thiomethyl; derivatives natural; natural phaeosphaeride; activity ... See more keywords
Synthesis of natural phaeosphaeride A and semi-natural phaeosphaeride B derivatives
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DOI: 10.1016/j.mencom.2017.09.020
Abstract: 6-O-Acylated phaeosphaeride A and phaeosphaeride B in reaction with secondary cyclic amines undergo stereospecific replacement of acyloxy group by pharmacophoric amino moiety. In case of chloroacetoxy derivative, chlorine displacement by such amines proceeds in the… read more here.
Keywords: semi natural; phaeosphaeride; phaeosphaeride semi; synthesis natural ... See more keywords