Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase‐1 Inhibitors by Automated De Novo Design
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100832
Abstract: Abstract The repertoire of natural products offers tremendous opportunities for chemical biology and drug discovery. Natural product‐inspired synthetic molecules represent an ecologically and economically sustainable alternative to the direct utilization of natural products. De novo… read more here.
Keywords: design; natural products; natural product; novo design ... See more keywords
Synthesis and antitumoral evaluation of natural product‐like compounds based on tropolone and benzotropolone derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200305
Abstract: We present the preparation of a series of novel natural product‐like homobarrelenones, norcaranes, and dihydrofluorenones through a diversity‐oriented synthetic (DOS) strategy that combines Diels–Alder reactions and phototransformations, as well as their biological evaluation against MCF‐7,… read more here.
Keywords: natural product; antitumoral evaluation; synthesis antitumoral; product like ... See more keywords
Computational modelling and invitro evaluation identified natural product - Z218 as a novel Janus Kinase-2 (JAK2) inhibitor to combat Beta Thalassemia.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2459
Abstract: Aberrant activity of Janus kinase 2 (JAK2) is a known driver of several myeloproliferative disorders, including polycythemia Vera, and Thalassemia. Several inhibitors have been proposed to inhibit JAK2 activity in order to control the disease… read more here.
Keywords: kinase jak2; kinase; jak2; natural product ... See more keywords
Small Molecules Inspired by the Natural Product Withanolides as Potent Inhibitors of Wnt Signaling
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700260
Abstract: Wnt signaling is a fundamental pathway that drives embryonic development and is essential for stem cell maintenance and tissue homeostasis. Dysregulation of Wnt signaling is linked to various diseases, and a constitutively active Wnt pathway… read more here.
Keywords: wnt signaling; small molecules; inhibitors wnt; natural product ... See more keywords
Cell‐Free Exploration of the Natural Product Chemical Space
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000452
Abstract: Natural products and secondary metabolites comprise an indispensable resource from living organisms that have transformed areas of medicine, agriculture, and biotechnology. Recent advances in high‐throughput DNA sequencing and computational analysis suggest that the vast majority… read more here.
Keywords: chemical space; chemical; natural product; cell free ... See more keywords
Design of Natural‐Product‐Inspired Multitarget Ligands by Machine Learning
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900097
Abstract: A virtual screening protocol based on machine learning models was used to identify mimetics of the natural product (−)‐galantamine. This fully automated approach identified eight compounds with bioactivities on at least one of the macromolecular… read more here.
Keywords: machine; machine learning; design natural; product inspired ... See more keywords
Solvent-induced Gel Formation Hypothesis for Natural Product Gelators with Polycyclic Structures.
Sign Up to like & getrecommendations! Published in 2018 at "ChemPlusChem"
DOI: 10.1002/cplu.201800334
Abstract: Natural products have long been used as pharmaceutical actives for the treatment of diseases. More recently, natural products with the ability to self-assemble to form soft material-gels, i.e. natural product gelators (NPGs), were discovered. This… read more here.
Keywords: gel formation; product gelators; formation; induced gel ... See more keywords
Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2891
Abstract: Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain. Calls to US poison centers involving kratom exposures increased >50‐fold… read more here.
Keywords: interaction potential; kratom; drug interaction; natural product ... See more keywords
Recent Applications of Rh‐ and Pd‐Catalyzed C(sp3)–H Functionalization in Natural Product Total Synthesis
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700641
Abstract: The advent of C(sp3)–H functionalization has heralded a paradigm shift in natural product synthesis. Indeed, several reports in which C–H functionalization serves as the key step in the synthesis have appeared over the years. The… read more here.
Keywords: sp3 functionalization; catalyzed sp3; total synthesis; natural product ... See more keywords
Polyphenolic natural products and natural product–inspired steroidal mimics as aromatase inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21536
Abstract: The discovery of biologically active polyphenolic natural products, including chalcones, stilbenes, flavanones, and isoflavones as steroidal mimics has proven to be a subject of considerable importance in medicine. Some of these natural compounds have been… read more here.
Keywords: natural products; aromatase inhibitors; natural product; polyphenolic natural ... See more keywords
Natural product‐based nanomedicine applied to fungal infection treatment: A review of the last 4 years
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7460
Abstract: Fungal infections are one of the main public health problems, especially in immunocompromised patients, nosocomial environments, patients with chronic diseases, and transplant recipients. These diseases are increasingly frequent and lethal because the microorganism has a… read more here.
Keywords: natural products; nanomedicine applied; based nanomedicine; product based ... See more keywords