Cotton flower metabolites inhibit SARS‐CoV‐2 main protease
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13477
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been spreading globally for over 2 years, causing serious contagious disease and incalculable damage. The introduction of vaccines has slowed the spread of SARS‐CoV‐2 to some extent, but… read more here.
Keywords: natural products; cotton; cotton flower; cov main ... See more keywords
Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase‐1 Inhibitors by Automated De Novo Design
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100832
Abstract: Abstract The repertoire of natural products offers tremendous opportunities for chemical biology and drug discovery. Natural product‐inspired synthetic molecules represent an ecologically and economically sustainable alternative to the direct utilization of natural products. De novo… read more here.
Keywords: design; natural products; natural product; novo design ... See more keywords
Microparticles enhance the formation of seven major classes of natural products in native and metabolically engineered actinobacteria through accelerated morphological development
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27818
Abstract: Actinobacteria provide a rich spectrum of bioactive natural products and therefore display an invaluable source towards commercially valuable pharmaceuticals and agrochemicals. Here, we studied the use of inorganic talc microparticles (hydrous magnesium silicate, 3MgO·4SiO2·H2O, 10 µm)… read more here.
Keywords: production; formation seven; natural products; enhance formation ... See more keywords
Core Steps to the Azaphilone Family of Fungal Natural Products
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DOI: 10.1002/cbic.202100240
Abstract: Azaphilones are a family of polyketide‐based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the… read more here.
Keywords: family fungal; natural products; fungal natural; core steps ... See more keywords
Genetic Survey of Psilocybe Natural Products
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DOI: 10.1002/cbic.202200249
Abstract: Psilocybe magic mushrooms are best known for their main natural product, psilocybin, and its dephosphorylated congener, the psychedelic metabolite psilocin. Beyond tryptamines, the secondary metabolome of these fungi is poorly understood. The genomes of five… read more here.
Keywords: survey psilocybe; natural products; psilocybe natural; genetic survey ... See more keywords
Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities
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DOI: 10.1002/cbic.202200341
Abstract: Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2,5‐diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety. Modifications of the core and the amino acid side chains, for example by… read more here.
Keywords: products building; biosynthesis; natural products; building blocks ... See more keywords
Biosynthetic Pathways of Dimeric Natural Products Containing Bisanthraquinone and Related Xanthones
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DOI: 10.1002/cbic.202200586
Abstract: Many dimeric natural products containing bisanthraquinone and related xanthones with diverse structures and versatile bioactivities have been isolated over the years. However, the complicated biosynthetic pathways of such natural products, which have remained elusive until… read more here.
Keywords: dimeric natural; products containing; natural products; related xanthones ... See more keywords
Racemization of Secondary‐Amine‐Containing Natural Products Using Heterogeneous Metal Catalysts
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DOI: 10.1002/cctc.201800293
Abstract: Heterogeneously catalyzed racemization reactions of the secondary amines (S)‐1‐methyl‐6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline (salsolidine) and (S)‐1‐methyl‐1,2,3,4‐tetrahydro‐ß‐carboline were investigated using Pd, Pt, and Ir on carbon or Al2O3 supports. A comparison of kinetics and deactivation on selected platinum and iridium… read more here.
Keywords: platinum; natural products; containing natural; amine containing ... See more keywords
Natural Products from Annonaceae as Potential Antichagasic Agents
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DOI: 10.1002/cmdc.202200196
Abstract: Chagas disease, a neglected tropical disease, is endemic in 21 Latin American countries and particularly prevalent in Brazil. Chagas disease has drawn more attention in recent years due to its expansion into non‐endemic areas. The aim… read more here.
Keywords: antichagasic agents; six molecules; natural products; form ... See more keywords
Natural products and their analogues acting against Mycobacterium tuberculosis: A recent update.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22063
Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases caused by Mycobacterium tuberculosis (M.tb). It is responsible for significant causes of mortality and morbidity worldwide. M.tb possesses robust defense mechanisms against most antibiotic drugs and… read more here.
Keywords: mycobacterium tuberculosis; products analogues; tuberculosis; natural products ... See more keywords
The Aza‐Prins Reaction in the Synthesis of Natural Products and Analogues
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201601411
Abstract: The classical Prins cyclization reaction has been one of the most studied reactions during the last two decades and it has found many applications in key steps of natural product syntheses, especially for products containing… read more here.
Keywords: natural products; prins reaction; reaction; prins cyclization ... See more keywords