Natural terpenoid glycosides with in vitro/vivo antithrombotic profiles from the leaves of Crataegus pinnatifida
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DOI: 10.1039/c7ra10768d
Abstract: Two norditerpenoids (1–2) with unique carbon skeletons, four sesquiterpenoids (3–6) and nine nor-sesquiterpenoids (7–15) were isolated from the leaves of Crataegus pinnatifida and evaluated as possessing antithrombotic activities in vitro/vivo. Their structures with absolute configurations… read more here.
Keywords: vitro vivo; natural terpenoid; terpenoid glycosides; crataegus pinnatifida ... See more keywords
Computational identification of potential natural terpenoid inhibitors of MDM2 for breast cancer therapy: molecular docking, molecular dynamics simulation, and ADMET analysis
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DOI: 10.3389/fchem.2025.1527008
Abstract: Background Breast cancer (BC) remains a leading cause of cancer-related mortality in women. The oncoprotein MDM2 negatively regulates the tumor suppressor p53, and its overexpression in BC promotes tumor progression and resistance to therapy. Targeting… read more here.
Keywords: natural terpenoid; cancer; breast cancer; admet analysis ... See more keywords