Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_55
Abstract: Mutations causing single amino acid exchanges can dramatically affect protein stability and function, leading to disease. In this chapter, we will focus on several representative cases in which such mutations affect protein stability and function… read more here.
Keywords: affect protein; function; small molecules; natural unnatural ... See more keywords
Post-translational mutagenesis for installation of natural and unnatural amino acid side chains into recombinant proteins
Sign Up to like & getrecommendations! Published in 2017 at "Nature Protocols"
DOI: 10.1038/nprot.2017.087
Abstract: Methods for installing natural and unnatural amino acids and their modifications into proteins in a benign and precise manner are highly sought-after in protein science. Here we describe a protocol for 'post-translational mutagenesis' that enables… read more here.
Keywords: mutagenesis; side chains; post translational; natural unnatural ... See more keywords
α,ω-Diacyl-Substituted Analogues of Natural and Unnatural Polyamines: Identification of Potent Bactericides That Selectively Target Bacterial Membranes
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DOI: 10.3390/ijms24065882
Abstract: In this study, α-ω-disubstituted polyamines exhibit a range of potentially useful biological activities, including antimicrobial and antibiotic potentiation properties. We have prepared an expanded set of diarylbis(thioureido)polyamines that vary in central polyamine core length, identifying… read more here.
Keywords: analogues natural; bacterial membranes; diacyl substituted; substituted analogues ... See more keywords