Nature of Irreversible Inhibition of Human 20S Proteasome by Salinosporamide A. The Critical Role of Lys–Asp Dyad Revealed from Electrostatic Effects Analysis
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DOI: 10.1021/acscatal.0c05313
Abstract: 20S proteasome is the enzymatic core engine involved in the processes of cellular protein regulation, thus becoming a promising target inter alia in the therapy of many diseases. In this work, the ... read more here.
Keywords: nature irreversible; proteasome salinosporamide; inhibition human; 20s proteasome ... See more keywords