Design, Synthesis, and Evaluation of Novel Benzo[d]isoxazole Derivatives as Anticonvulsants by Selectively Blocking the Voltage-Gated Sodium Channel NaV1.1.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00846
Abstract: Sodium channel blockers are important antiseizure drugs. Since the launch of phenobarbital in 1912, it has a development history of nearly 100 years. However, because of the confounding symptoms, complications, and complex intrinsic pathogenesis of… read more here.
Keywords: benzo isoxazole; channel; isoxazole derivatives; sodium channel ... See more keywords
Reversible lysine acetylation: Another layer of post-translational regulation of the cardiac sodium channel
Sign Up to like & getrecommendations! Published in 2017 at "Channels"
DOI: 10.1080/19336950.2017.1340015
Abstract: Nav1.5, the voltage-gated cardiac Na C channel, conducts the inward NaC current (INa), which is the main depolarizing current responsible for initiation and propagation of the cardiac action potential. Mutations in SCN5A, the gene encoding… read more here.
Keywords: channel; cardiac sodium; post translational; nav1 ... See more keywords
Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice
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DOI: 10.1126/scisignal.aah4874
Abstract: The voltage-gated Na+ channel Nav1.7 controls the balance of pain-promoting and pain-relieving receptor input. Channeling pain through GPCRs Identification of Nav1.7 as responsible for the absence of pain sensitivity in humans has prompted the investigation… read more here.
Keywords: opioid signaling; nav1; mice; nav1 knockout ... See more keywords
Local Anesthetic Like Inhibition of the Cardiac Na+ Channel Nav1.5 by Chloroquine and Hydroxychloroquine
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DOI: 10.2147/jep.s375349
Abstract: Introduction Chloroquine (CQ) and its derivate hydroxychloroquine (HCQ) are successfully deployed for different diseases beyond the prophylaxis and treatment of malaria. Both substances exhibit antiviral properties and have been proposed for prophylaxis and treatment of… read more here.
Keywords: cardiac channel; inhibition; anesthetic like; local anesthetic ... See more keywords
Mice Heterozygous for the Sodium Channel Scn8a (Nav1.6) Have Reduced Inflammatory Responses During EAE and Following LPS Challenge
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.533423
Abstract: Voltage gated sodium (Nav) channels contribute to axonal damage following demyelination in experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis (MS). The Nav1.6 isoform has been implicated as a primary contributor in this… read more here.
Keywords: inflammatory responses; lps challenge; nav1; mice ... See more keywords
Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1130123
Abstract: Patients treated with paclitaxel (PTX) or other antineoplastic agents can experience chemotherapy-induced peripheral neuropathy (CIPN), a debilitating side effect characterized by numbness and pain. PTX interferes with microtubule-based transport, which inhibits tumor growth via cell… read more here.
Keywords: paclitaxel effects; effects axonal; nav1 channels; trafficking nav1 ... See more keywords
Mutations in NaV1.5 Reveal Calcium-Calmodulin Regulation of Sodium Channel
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DOI: 10.3389/fphys.2019.00700
Abstract: Mutations in the SCN5A gene, encoding the cardiac voltage-gated sodium channel NaV1.5, are associated with inherited cardiac arrhythmia and conduction disease. Ca2+-dependent mechanisms and the involvement of β-subunit (NaVβ) in NaV1.5 regulation are not fully… read more here.
Keywords: cam; sodium channel; nav1; channel ... See more keywords
Voltage-Gated Sodium Channel NaV1.7 Inhibitors with Potent Anticancer Activities in Medullary Thyroid Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15102806
Abstract: Simple Summary Despite the recent advances in the diagnosis and treatment of medullary thyroid cancer (MTC), it remains an understudied cancer type and continues to disproportionately contribute to thyroid-cancer-related mortality. In this manuscript, we report,… read more here.
Keywords: mtc; channel; thyroid; thyroid cancer ... See more keywords
Differential Effect of Three Macrolide Antibiotics on Cardiac Pathology and Electrophysiology in a Myocardial Infarction Rat Model: Influence on Sodium Nav1.5 Channel Expression
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DOI: 10.3390/ph14070597
Abstract: Macrolides were reported to have cardiotoxic effects presented mainly by electrocardiogram (ECG) changes with increased risk in cardiac patients. We aimed to determine the impact of three macrolides, azithromycin, clarithromycin and erythromycin, on cardiac electrophysiology,… read more here.
Keywords: healthy rats; channel expression; nav1; pathology ... See more keywords