Pathogenic mutations perturb calmodulin regulation of Nav1.8 channel.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.08.010
Abstract: The voltage-gated sodium channels play a key role in the generation and propagation of the cardiac action potential. Emerging data indicate that the Nav1.8 channel, encoded by the SCN10A gene, is a modulator of cardiac… read more here.
Keywords: cam; regulation nav1; channel; inactivation ... See more keywords
Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114495
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Allium macrostemon Bunge. is an edible Chinese herb traditionally used for the treatment of thoracic pain, stenocardia, heart asthma and diarrhea. Although its biological potential has been extensively proven such as antioxidant activity,… read more here.
Keywords: macrostemon; nav1 channel; allium macrostemon; analgesic activity ... See more keywords
Role of Nuclear Lamin A/C in the Regulation of Nav1.5 Channel and Microtubules: Lesson From the Pathogenic Lamin A/C Variant Q517X
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.918760
Abstract: In this work, we studied an lmna nonsense mutation encoding for the C-terminally truncated Lamin A/C (LMNA) variant Q517X, which was described in patients affected by a severe arrhythmogenic cardiomyopathy with history of sudden death.… read more here.
Keywords: nav1 channel; q517x; variant q517x; tubulin ... See more keywords
The NaV1.7 Channel Subtype as an Antinociceptive Target for Spider Toxins in Adult Dorsal Root Ganglia Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01000
Abstract: Although necessary for human survival, pain may sometimes become pathologic if long-lasting and associated with alterations in its signaling pathway. Opioid painkillers are officially used to treat moderate to severe, and even mild, pain. However,… read more here.
Keywords: antinociceptive target; channel subtype; subtype antinociceptive; target spider ... See more keywords
Diagnostic yield and variant reassessment in the genes encoding Nav1.5 channel in Russian patients with Brugada syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.984299
Abstract: Brugada syndrome (BrS) is an inherited cardiac arrhythmia characterized by ST-elevation, negative T-wave, and a high risk of sudden cardiac death (SCD) due to ventricular tachycardia. It is associated with mutations in over 20 genes… read more here.
Keywords: nav1 channel; genes encoding; encoding nav1; diagnostic yield ... See more keywords
Kinetic Alterations in Resurgent Sodium Currents of Mutant Nav1.4 Channel in Two Patients Affected by Paramyotonia Congenita
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11040613
Abstract: Simple Summary Paramyotonia congenita (PMC) is a rare muscle disorder that causes myotonia and weakness of facial and limb muscles. The electromyography in PMC shows continual spontaneous, high-frequency spike potentials in skeletal muscles. Genetic mutations… read more here.
Keywords: pmc; nav1 channel; paramyotonia congenita; mutant nav1 ... See more keywords
Differential Effect of Three Macrolide Antibiotics on Cardiac Pathology and Electrophysiology in a Myocardial Infarction Rat Model: Influence on Sodium Nav1.5 Channel Expression
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14070597
Abstract: Macrolides were reported to have cardiotoxic effects presented mainly by electrocardiogram (ECG) changes with increased risk in cardiac patients. We aimed to determine the impact of three macrolides, azithromycin, clarithromycin and erythromycin, on cardiac electrophysiology,… read more here.
Keywords: healthy rats; channel expression; nav1; pathology ... See more keywords
[Corrigendum] Blocking the Nav1.5 channel using eicosapentaenoic acid reduces migration and proliferation of ovarian cancer cells.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of oncology"
DOI: 10.3892/ijo.2020.5129
Abstract: Following the publication of this article, the authors regret that they did not make it clear which author was funded by the funding bodies. The information in the "Funding" part of the paper should therefore… read more here.
Keywords: channel using; corrigendum blocking; oncology; blocking nav1 ... See more keywords