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   Articles with "nav1 channels" as a keyword



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Virtual Screening in Search of Allosteric Modulators of Nav1.1 Channels

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.1325

Abstract: Voltage-gated Na+ (Nav) channels provide the basis for neuronal excitability in the brain. Of the nine Nav channel isoforms (Nav1.1-Nav1.9), Nav1.1 exhibits cell-specific distribution in fast-spiking parvalbumin (PV) interneurons in the cortical circuit. Reduced function… read more here.

Keywords: virtual screening; search allosteric; fgf14 nav1; screening search ... See more keywords
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Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.01.025

Abstract: SUMMARY Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive,… read more here.

Keywords: cardiac myocytes; late sodium; sumoylation nav1; sodium current ... See more keywords
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The invasiveness of human cervical cancer associated to the function of NaV1.6 channels is mediated by MMP-2 activity

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-31364-y

Abstract: Voltage-gated sodium (NaV) channels have been related with cell migration and invasiveness in human cancers. We previously reported the contribution of NaV1.6 channels activity with the invasion capacity of cervical cancer (CeCa) positive to Human… read more here.

Keywords: invasiveness human; nav1 channels; ceca; cancer ... See more keywords
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Focal and generalized seizure activity after local hippocampal or cortical ablation of NaV1.1 channels in mice

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recommendations! Published in 2020 at "Epilepsia"

DOI: 10.1111/epi.16482

Abstract: Early onset seizures are a hallmark of Dravet syndrome. Previous studies in rodent models have shown that the epileptic phenotype is caused by loss‐of‐function of voltage‐gated NaV1.1 sodium channels, which are chiefly expressed in γ‐aminobutyric… read more here.

Keywords: ablation nav1; ablation; nav1 channels; seizure ... See more keywords
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Persistent and resurgent Na+ currents in vestibular calyx afferents.

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recommendations! Published in 2020 at "Journal of neurophysiology"

DOI: 10.1152/jn.00124.2020

Abstract: Vestibular afferent neurons convey information from hair cells in vestibular end organs to central nuclei. These neurons can fire action potentials at high rates and firing patterns vary with the position of nerve terminal endings… read more here.

Keywords: mature; mature calyces; resurgent currents; calyx afferents ... See more keywords
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NaV1.9 channels in muscle afferent neurons and axons.

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recommendations! Published in 2018 at "Journal of neurophysiology"

DOI: 10.1152/jn.00573.2017

Abstract: The exercise pressor reflex (EPR) is activated by muscle contractions to increase heart rate and blood pressure during exercise. While this reflex is beneficial in healthy individuals, the reflex activity is exaggerated in patients with… read more here.

Keywords: muscle; muscle afferent; afferent neurons; nav1 current ... See more keywords
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Brugada syndrome trafficking-defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels.

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recommendations! Published in 2018 at "JCI insight"

DOI: 10.1172/jci.insight.96291

Abstract: Cardiac Nav1.5 and Kir2.1-2.3 channels generate Na (INa) and inward rectifier K (IK1) currents, respectively. The functional INa and IK1 interplay is reinforced by the positive and reciprocal modulation between Nav15 and Kir2.1/2.2 channels to… read more here.

Keywords: kir2 channels; nav1 channels; defective nav1; trafficking defective ... See more keywords
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Paclitaxel effects on axonal localization and vesicular trafficking of NaV1.8

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recommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2023.1130123

Abstract: Patients treated with paclitaxel (PTX) or other antineoplastic agents can experience chemotherapy-induced peripheral neuropathy (CIPN), a debilitating side effect characterized by numbness and pain. PTX interferes with microtubule-based transport, which inhibits tumor growth via cell… read more here.

Keywords: paclitaxel effects; effects axonal; nav1 channels; trafficking nav1 ... See more keywords
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Blockers of Skeletal Muscle Nav1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back

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recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24010857

Abstract: The voltage-gated sodium channels represent an important target for drug discovery since a large number of physiological processes are regulated by these channels. In several excitability disorders, including epilepsy, cardiac arrhythmias, chronic pain, and non-dystrophic… read more here.

Keywords: muscle nav1; blockers skeletal; muscle; nav1 channels ... See more keywords