Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice
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DOI: 10.1126/scisignal.aah4874
Abstract: The voltage-gated Na+ channel Nav1.7 controls the balance of pain-promoting and pain-relieving receptor input. Channeling pain through GPCRs Identification of Nav1.7 as responsible for the absence of pain sensitivity in humans has prompted the investigation… read more here.
Keywords: opioid signaling; nav1; mice; nav1 knockout ... See more keywords