Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment.
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DOI: 10.1016/j.vascn.2021.107125
Abstract: INTRODUCTION For reliable identification of cardiac safety risk, compounds should be screened for activity on cardiac ion channels in addition to hERG, including NaV1.5 and CaV1.2. We identified different parameters that might affect IC50s of… read more here.
Keywords: identification cardiac; patch clamp; automated patch; nav1 peak ... See more keywords