Functional reconstitution of rat Nav1.6 sodium channels in vitro for studies of pyrethroid action
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2016.03.010
Abstract: HIGHLIGHTSMammalian neurons express multiple sodium channel subunit complexes.Reconstitution in vitro allows the study of individual subunits and complexes.Xenopus oocytes and HEK293 yield channels with different properties.Channels in HEK293 cells exhibit properties similar to channels in… read more here.
Keywords: pyrethroid action; sodium; nav1 sodium; rat nav1 ... See more keywords
Deciphering in silico the Role of Mutated NaV1.1 Sodium Channels in Enhancing Trigeminal Nociception in Familial Hemiplegic Migraine Type 3
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.644047
Abstract: Familial hemiplegic migraine type 3 (FHM3) is caused by gain-of-function mutations in the SCN1A gene that encodes the α1 subunit of voltage-gated NaV1.1 sodium channels. The high level of expression of NaV1.1 channels in peripheral… read more here.
Keywords: migraine; familial hemiplegic; nav1 sodium; migraine type ... See more keywords