The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis.
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DOI: 10.1182/blood.2019004276
Abstract: Studies of inherited platelet disorders have provided many insights into platelet development and function. Loss of function of neurobeachin-like 2 (NBEAL2) causes Gray Platelet Syndrome (GPS), where the absence of platelet α-granules indicates NBEAL2 is… read more here.
Keywords: biogenesis; endoplasmic reticulum; reticulum; nbeal2 required ... See more keywords