Structural bases for Na+-Cl− cotransporter inhibition by thiazide diuretic drugs and activation by kinases
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DOI: 10.1038/s41467-024-51381-y
Abstract: The Na+-Cl− cotransporter (NCC) drives salt reabsorption in the kidney and plays a decisive role in balancing electrolytes and blood pressure. Thiazide and thiazide-like diuretics inhibit NCC-mediated renal salt retention and have been cornerstones for… read more here.
Keywords: ncc ion; activation; thiazide like; ion translocation ... See more keywords