In vivo efficacy studies of novel quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors, in lung cancer xenografts (NCI-H1975) mice models.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103790
Abstract: Lung cancer is the most common cancer and leading cause of cancer-related deaths worldwide. The first-generation reversible, ATP-competitive inhibitors gefetinib and elotinib showed good clinical responses in lung adenocarcinoma tumors (NSCLC). But almost all patients… read more here.
Keywords: efficacy studies; nci h1975; generation; lung cancer ... See more keywords
Combination of azacitidine and trichostatin A decreased the tumorigenic potential of lung cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "OncoTargets and therapy"
DOI: 10.2147/ott.s136218
Abstract: Purpose This study aims to investigate the possibility of using epigenetic inhibitors against lung cancer. Methods The changes in the proliferation of human lung cancer cells, NCI-H1975 and NCI-H1299 cells, treated with various doses of… read more here.
Keywords: lung cancer; nci h1975; cancer cells; cancer ... See more keywords
Thermal treatment decreases resistance to osimertinib in non-small cell lung cancer through the EGFR/PI3K/AKT pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Neoplasma"
DOI: 10.4149/neo_2021_200506n489
Abstract: Osimertinib (OSI) resistance commonly occurs during the treatment of non-small-cell lung cancer (NSCLC). This study aims to investigate whether the thermal effects of radiofrequency ablation (RFA) can increase the sensitivity of OSI-resistant NSCLC to OSI… read more here.
Keywords: treatment; h1975; h1975 osir; cell ... See more keywords