Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1924545
Abstract: Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) and Homeobox A5 (HOXA5) are both down-regulated in adrenocortical carcinoma (ACC), and HOXA5 is predicted to bind to the promoter of AKR1B10. We aimed to investigate whether HOXA5… read more here.
Keywords: nci h295r; hoxa5; akr1b10; apoptosis ... See more keywords
Adrenocortical cancer cell line mutational profile reveals aggressive genetic background.
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DOI: 10.1530/jme-18-0262
Abstract: Adrenocortical carcinomas are rare tumors with poor prognosis and limited treatment options. Although widely used as in vitro models to test novel therapeutic strategies, the adrenocortical carcinoma-derived cell lines NCI-H295R and SW-13 have been only… read more here.
Keywords: nci h295r; adrenocortical cancer; cell; adrenocortical carcinoma ... See more keywords
N-type calcium channel v2.2 is a target of TCF21 in adrenocortical carcinomas.
Sign Up to like & getrecommendations! Published in 2022 at "Neoplasma"
DOI: 10.4149/neo_2022_220106n25
Abstract: Transcription factor 21 (TCF21) directly binds and regulates SF1 mRNA expression in tumor and normal adrenocortical cells, and both are involved in the development and steroidogenesis of the adrenal cortex. TCF21 is a tumor suppressor… read more here.
Keywords: calcium channel; expression; type calcium; adrenocortical carcinomas ... See more keywords