Mesenchymal chondrosarcoma of the head and neck with HEY1::NCOA2 fusion: A clinicopathologic and molecular study of 13 cases with emphasis on diagnostic pitfalls
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DOI: 10.1002/gcc.23075
Abstract: Mesenchymal chondrosarcoma (MCS) is a rare translocation‐associated sarcoma, driven by a canonical HEY1::NCOA2 fusion. The tumors typically have a biphasic phenotype of primitive small blue round cells intermixed with hyaline cartilage. The head and neck… read more here.
Keywords: head neck; mesenchymal chondrosarcoma; ncoa2 fusion; chondrosarcoma head ... See more keywords
Pineal alveolar rhabdomyosarcoma with PAX3:NCOA2 fusion inducing OLIG2 expression, a potential pitfall in the central nervous system
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DOI: 10.1111/his.14364
Abstract: A previously healthy 12-year-old boy began experiencing intracranial hypertension symptoms. Cerebral magnetic resonance imaging (MRI) showed a pineal mass. Cerebrospinal fluid and blood tested negative for β-human chorionic gonadotrophin, α-foetoprotein, carcinoembryonic antigen, and placental alkaline… read more here.
Keywords: fusion inducing; pax3 ncoa2; ncoa2 fusion; rhabdomyosarcoma pax3 ... See more keywords
Abstract 3359: HEY1::NCOA2 fusion disturbs the transcriptional program of chondrogenic differentiation and activates oncogenes in mesenchymal chondrosarcoma tumorigenesis
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DOI: 10.1158/1538-7445.am2024-3359
Abstract: Mesenchymal chondrosarcoma (MCS) is a rare high-grade mesenchymal neoplasm occurring in bone and soft tissue. It accounts for 2%~10% of all chondrosarcomas and affects mainly adolescents and young adults. Genetically, this tumor is characterized by… read more here.
Keywords: differentiation; chondrogenic differentiation; hey1 ncoa2; ncoa2 fusion ... See more keywords