USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3
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DOI: 10.1126/sciadv.abq7598
Abstract: Ubiquitin-specific protease 7 (USP7) has been implicated in cancer progression and neurodevelopment. However, its molecular targets remain poorly characterized. We combined quantitative proteomics, transcriptomics, and epigenomics to define the core USP7 network. Our multi-omics analysis… read more here.
Keywords: ncprc1 polycomb; uncoupled h3k27me3; deposition; h2ak119ub1 ... See more keywords