Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments
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DOI: 10.7554/elife.36392
Abstract: Proper kinetochore-microtubule attachments, mediated by the NDC80 complex, are required for error-free chromosome segregation. Erroneous attachments are corrected by the tension dependence of kinetochore-microtubule interactions. Here, we present a method, based on fluorescence lifetime imaging… read more here.
Keywords: tension; kinetochore microtubule; microtubule attachments; ndc80 binding ... See more keywords