NDP‐MSH reduces oxidative damage induced by palmitic acid in primary astrocytes
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12673
Abstract: Recent findings relate obesity to inflammation in key hypothalamic areas for body weight control. Hypothalamic inflammation has also been related to oxidative stress. Palmitic acid (PA) is the most abundant free fatty acid found in… read more here.
Keywords: msh reduces; palmitic acid; ndp msh; reduces oxidative ... See more keywords
NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1591-4
Abstract: BackgroundNeuroinflammation and blood-brain barrier (BBB) disruption are two vital mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently, melanocortin-1 receptor (Mc1r) activation by Nle4-D-Phe7-α-MSH (NDP-MSH) was shown to play a neuroprotective role in an… read more here.
Keywords: mc1r; bbb disruption; ndp msh; neuroinflammation bbb ... See more keywords
Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1082036
Abstract: Introduction Alzheimer’s disease (AD) is the most frequent cause of dementia and still lacks effective therapy. Clinical signs of AD include low levels of endogenous melanocortins (MCs) and previous studies have shown that treatment with… read more here.
Keywords: 3xtg mice; ndp msh; mice; stages progression ... See more keywords