Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome
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DOI: 10.1002/glia.24234
Abstract: Leigh syndrome is a mitochondrial disease characterized by neurodegeneration, neuroinflammation, and early death. Mice lacking NDUFS4, a mitochondrial complex I subunit (Ndufs4 KO mice), have been established as a good animal model for studying human… read more here.
Keywords: ndufs4 mice; neuroinflammation; disease; pathology ... See more keywords