Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria
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DOI: 10.1098/rsob.210255
Abstract: Mutations in Parkin and PINK1 cause early-onset familial Parkinson's disease. Parkin is a RING-In-Between-RING E3 ligase that transfers ubiquitin from an E2 enzyme to a substrate in two steps: (i) thioester intermediate formation on Parkin… read more here.
Keywords: near pink1; selective localization; ubiquitination; parkin mitochondria ... See more keywords