From bench to bedside: in vitro and in vivo evaluation of a neonate-focused nebulized surfactant delivery strategy
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DOI: 10.1186/s12931-019-1096-9
Abstract: BackgroundNon-invasive delivery of nebulized surfactant has been a neonatology long-pursued goal. Nevertheless, the clinical efficacy of nebulized surfactant remains inconclusive, in part, due to the great technical challenges of depositing nebulized drugs in the lungs… read more here.
Keywords: poractant alfa; delivery; nebulized surfactant; delivery strategy ... See more keywords
Preclinical Assessment of Nebulized Surfactant Delivered through Neonatal High Flow Nasal Cannula Respiratory Support
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DOI: 10.3390/pharmaceutics14051093
Abstract: High-flow nasal cannula (HFNC) is a non-invasive respiratory support (NRS) modality to treat premature infants with respiratory distress syndrome (RDS). The delivery of nebulized surfactant during NRS would represent a truly non-invasive method of surfactant… read more here.
Keywords: lung; flow nasal; high flow; nebulized surfactant ... See more keywords