Proteomic characterization and comparison of the infective and adult life stage secretomes from Necator americanus and Ancylostoma ceylanicum
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DOI: 10.1371/journal.pntd.0012780
Abstract: More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management approaches are limited by modest… read more here.
Keywords: ancylostoma ceylanicum; necator americanus; adult life; stage ... See more keywords
Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates
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DOI: 10.1371/journal.pntd.0012809
Abstract: Background The antigen Na-GST-1, expressed by the hookworm Necator americanus, plays crucial biochemical roles in parasite survival. This study explores the development of mRNA vaccine candidates based on Na-GST-1, building on the success of recombinant… read more here.
Keywords: vaccine candidates; mrna; antigen; necator americanus ... See more keywords
Necator americanus Ancylostoma Secreted Protein-2 (Na-ASP-2) Binds an Ascaroside (ascr#3) in Its Fatty Acid Binding Site
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DOI: 10.3389/fchem.2020.608296
Abstract: During their infective stages, hookworms release excretory-secretory (E-S) products, small molecules, and proteins to help evade and suppress the host's immune system. Small molecules found in E-S products of mammalian hookworms include nematode derived metabolites… read more here.
Keywords: hookworm products; fatty acid; necator americanus; secreted protein ... See more keywords