HSF1 activates the FOXO3a–ΔNp63α–CDK4 axis to promote head and neck squamous cell carcinoma cell proliferation and tumour growth
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14588
Abstract: Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers worldwide. Heat shock factor 1 (HSF1) is a conserved transcriptional factor that plays a critical role in maintaining cellular proteostasis. However,… read more here.
Keywords: cell; hsf1; tumour growth; head neck ... See more keywords
Genetic analysis of single disseminated tumor cells in the lymph nodes and bone marrow of patients with head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13113
Abstract: Considering the limited information on the biology and molecular characteristics of disseminated tumor cells (DTCs) in head and neck squamous cell carcinoma (HNSCC), we examined the genomic alterations in DTCs from HNSCCs and their potential… read more here.
Keywords: neck squamous; disseminated tumor; tumor cells; biology ... See more keywords
T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13131
Abstract: Better management of head and neck squamous cell carcinomas (HNSCCs) requires a clearer understanding of tumor biology and disease risk. Bitter taste receptors (T2Rs) have been studied in several cancers, including thyroid, salivary, and GI,… read more here.
Keywords: neck squamous; taste receptors; squamous cell; bitter taste ... See more keywords
Human papilloma virus integration sites and genomic signatures in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13219
Abstract: A prevalence of around 26% of Human Papillomavirus (HPV) in Head and Neck Squamous Cell Carcinoma (HNSCC) has been previously reported. HPV induced oncogenesis mainly involves E6 and E7 viral onco-proteins. In some cases, HPV… read more here.
Keywords: cell carcinoma; neck squamous; integration; hpv ... See more keywords
Unraveling LINE-1 retrotransposition in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular oncology"
DOI: 10.1002/1878-0261.70063
Abstract: The relevant role of LINE‐1 (L1) retrotransposition in cancer has been recurrently demonstrated in recent years. However, the repetitive nature of retrotransposons makes their identification and detection inaccessible for clinical practice. Also, its clinical relevance… read more here.
Keywords: neck squamous; head neck; activation; squamous cell ... See more keywords
A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis‐Targeting Chimeras Enhanced Immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202210787
Abstract: Although immunotherapy has revolutionized oncotherapy, only ≈15% of head and neck squamous cell carcinoma (HNSCC) patients benefit from the current therapies. An immunosuppressive tumor microenvironment (TME) and dysregulation of the polycomb ring finger oncogene BMI1… read more here.
Keywords: cell; head neck; nanocomposite hydrogel; squamous cell ... See more keywords
CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202414961
Abstract: Due to the absence of effective biomarkers, the precision therapy of head and neck squamous cell carcinoma (HNSCC) still faces challenge. TP53 is one of the most frequently mutated genes in human cancers including HNSCC.… read more here.
Keywords: neck squamous; head neck; circtp53; progression ... See more keywords
Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression
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DOI: 10.1002/cac2.12273
Abstract: Cancer cells selectively promote the translation of oncogenic transcripts to stimulate cancer progression. Although growing evidence has revealed that tRNA modifications and related genes participate in this process, their roles in head and neck squamous… read more here.
Keywords: cell carcinoma; head neck; neck squamous; squamous cell ... See more keywords
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c‐Myc‐mediated positive feedback loop
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12349
Abstract: Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent malignancies worldwide and is characterized by unfavorable prognosis, high lymph node metastasis and early recurrence. However, the molecular events regulating HNSCC tumorigenesis… read more here.
Keywords: cell carcinoma; head neck; tumorigenesis; squamous cell ... See more keywords
MUC1 as a target for CAR‐T therapy in head and neck squamous cell carinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2733
Abstract: The modification of chimeric antigen receptor (CAR) endowing T cells with tumor‐specific cytotoxicity induces antitumor immunity. However, the structural characteristics of solid tumors, the loss of specific antigens, and the strong immunosuppressive environment are challenges… read more here.
Keywords: neck squamous; muc1; car; car therapy ... See more keywords
Cetuximab combined with paclitaxel or paclitaxel alone for patients with recurrent or metastatic head and neck squamous cell carcinoma progressing after EXTREME
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3953
Abstract: Prognosis of recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) remains poor. The addition of cetuximab, to platinum and fluorouracil chemotherapy (EXTREME regimen) has been shown to improve patients’ outcomes in first‐line… read more here.
Keywords: neck squamous; recurrent metastatic; metastatic head; cell carcinoma ... See more keywords