Necroptosis-Inducible Polymeric Nanobubbles for Enhanced Cancer Sonoimmunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.201907953
Abstract: Necroptosis, caspase-independent programmed necrosis, has emerged as a therapeutic target to make dying cancer cells stimulants for antitumor immune responses. The clinical translations exploiting necroptosis, however, have been limited since most cancer cells downregulate receptor-interacting… read more here.
Keywords: polymeric nanobubbles; necroptosis; nanobubbles enhanced; necroptosis inducible ... See more keywords
The Bulk Osteosarcoma and Osteosarcoma Stem Cell Activity of a Necroptosis‐Inducing Nickel(II)–Phenanthroline Complex
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000231
Abstract: We report the anti‐osteosarcoma and anti‐osteosarcoma stem cell (OSC) properties of a nickel(II) complex, 1. Complex 1 displays similar potency towards bulk osteosarcoma cells and OSCs, in the micromolar range. Notably, 1 displays similar or… read more here.
Keywords: necroptosis; osteosarcoma; osteosarcoma stem; stem cell ... See more keywords
Necroptotic TNFα‐Syndecan 4‐TNFα Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4542
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease for which the underlying mechanism still remains unclear. Compared with apoptosis and autophagy, necroptosis causes greater harm to tissue homeostasis by releasing damage‐associated molecular patterns (DAMPs).… read more here.
Keywords: necroptosis; vicious cycle; therapeutic target; tnf ... See more keywords
Necroptosis‐related lncRNA to establish novel prognostic signature and predict the immunotherapy response in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24302
Abstract: Necroptosis is a type of programmed cell death, and recent researches have showed that lncRNAs could regulate the process of necroptosis in multiple cancers. We tried to screen necroptosis‐related lncRNAs and investigate the immune landscape… read more here.
Keywords: breast cancer; necroptosis; necroptosis related; related lncrna ... See more keywords
Necroptosis is associated with Rab27‐independent expulsion of extracellular vesicles containing RIPK3 and MLKL
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12261
Abstract: Abstract Extracellular vesicle (EV) secretion is an important mechanism used by cells to release biomolecules. A common necroptosis effector—mixed lineage kinase domain like (MLKL)—was recently found to participate in the biogenesis of small and large… read more here.
Keywords: necroptosis associated; necroptosis; evs released; ripk3 mlkl ... See more keywords
Profiling of small-molecule necroptosis inhibitors based on the subpockets of kinase-ligand interactions.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21968
Abstract: Necroptosis is a highly regulated cell death (RCD) form in various inflammatory diseases. Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are involved in the pathway. Targeting the kinase domains of RIPK1 and/or 3 is a… read more here.
Keywords: necroptosis; kinase ligand; kinase domains; kinase ... See more keywords
The antagonistic effect of melatonin on TBBPA‐induced apoptosis and necroptosis via PTEN/PI3K/AKT signaling pathway in swine testis cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23595
Abstract: Tetrabromobisphenol A (TBBPA) is a widely used industrial brominated flame retardant, which can endanger animal and human health, including cytotoxicity, endocrine disruption, reproductive toxicity and so on. Melatonin (MT) is a noteworthy free radical scavenger… read more here.
Keywords: necroptosis; pi3k akt; tbbpa; expression ... See more keywords
Subversion of Programed Cell Death by Poxviruses.
Sign Up to like & getrecommendations! Published in 2021 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2020_229
Abstract: Poxviruses have been long regarded as potent inhibitors of apoptotic cell death. More recently, they have been shown to inhibit necroptotic cell death through two distinct strategies. These strategies involve either blocking virus sensing by… read more here.
Keywords: death; necroptosis; necroptotic cell; cell death ... See more keywords
Time-Lapse Imaging of Necroptosis and DAMP Release at Single-Cell Resolution.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1258-3_29
Abstract: Necroptosis is a regulated form of necrosis that depends on receptor-interacting protein kinase (RIPK)3 and mixed lineage kinase domain-like protein (MLKL). Necroptotic cells release a variety of cellular and nuclear factors, referred to as danger-associated… read more here.
Keywords: single cell; necroptosis; cell; cell resolution ... See more keywords
Necroptosis, the Other Main Caspase-Independent Cell Death.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-62026-4_7
Abstract: The past decades witnessed the discovery of novel modes of cell death, such as ferroptosis, pyroptosis and necroptosis, all of them presenting common necrotic traits. In this chapter, we revisit the early discoveries that unveiled… read more here.
Keywords: necroptosis main; necroptosis; main caspase; cell death ... See more keywords
Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2547-4
Abstract: Ferroptosis is a recently recognized caspase-independent form of regulated cell death that is characterized by the accumulation of lethal lipid ROS produced through iron-dependent lipid peroxidation. Considering that regulation of fatty acid metabolism is responsible… read more here.
Keywords: necroptosis; ferroptosis; cell death; failure ... See more keywords