Necroptosis-Inducible Polymeric Nanobubbles for Enhanced Cancer Sonoimmunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.201907953
Abstract: Necroptosis, caspase-independent programmed necrosis, has emerged as a therapeutic target to make dying cancer cells stimulants for antitumor immune responses. The clinical translations exploiting necroptosis, however, have been limited since most cancer cells downregulate receptor-interacting… read more here.
Keywords: polymeric nanobubbles; necroptosis; nanobubbles enhanced; necroptosis inducible ... See more keywords
Optogenetically Activatable MLKL as a Standalone Functional Module for Necroptosis and Therapeutic Applications in Antitumoral Immunity
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202412393
Abstract: Necroptosis plays a crucial role in the progression of various diseases and has gained substantial attention for its potential to activate antitumor immunity. However, the complex signaling networks that regulate necroptosis have made it challenging… read more here.
Keywords: therapeutic applications; immunity; optogenetically activatable; functional module ... See more keywords
Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis
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DOI: 10.1002/advs.202504406
Abstract: The peripheral immune system contributes to the development of sepsis‐induced cardiomyopathy. However, the underlying mechanisms linking central immune cells and neurons to sepsis‐induced cardiomyopathy remain to be clarified. Here, acute sepsis is induced by cecal… read more here.
Keywords: activation; gabaergic neuronal; necroptosis; sepsis induced ... See more keywords
The Bulk Osteosarcoma and Osteosarcoma Stem Cell Activity of a Necroptosis‐Inducing Nickel(II)–Phenanthroline Complex
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DOI: 10.1002/cbic.202000231
Abstract: We report the anti‐osteosarcoma and anti‐osteosarcoma stem cell (OSC) properties of a nickel(II) complex, 1. Complex 1 displays similar potency towards bulk osteosarcoma cells and OSCs, in the micromolar range. Notably, 1 displays similar or… read more here.
Keywords: necroptosis; osteosarcoma; osteosarcoma stem; stem cell ... See more keywords
Necroptotic TNFα‐Syndecan 4‐TNFα Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4542
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease for which the underlying mechanism still remains unclear. Compared with apoptosis and autophagy, necroptosis causes greater harm to tissue homeostasis by releasing damage‐associated molecular patterns (DAMPs).… read more here.
Keywords: necroptosis; vicious cycle; therapeutic target; tnf ... See more keywords
Spinal microglial M1 polarization contributes paclitaxel‐induced neuropathic pain by triggering cells necroptosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23669
Abstract: Paclitaxel (PTX) is a chemotherapeutic agent that is widely used for the treatment of several types of tumors. However, PTX‐induced peripheral neuropathy (PIPN) is an adverse effect generally induced by long‐term PTX use that significantly… read more here.
Keywords: ptx induced; microglial polarization; necroptosis; neuropathic pain ... See more keywords
Necroptosis‐related lncRNA to establish novel prognostic signature and predict the immunotherapy response in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24302
Abstract: Necroptosis is a type of programmed cell death, and recent researches have showed that lncRNAs could regulate the process of necroptosis in multiple cancers. We tried to screen necroptosis‐related lncRNAs and investigate the immune landscape… read more here.
Keywords: breast cancer; necroptosis; necroptosis related; related lncrna ... See more keywords
Necroptosis is associated with Rab27‐independent expulsion of extracellular vesicles containing RIPK3 and MLKL
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12261
Abstract: Abstract Extracellular vesicle (EV) secretion is an important mechanism used by cells to release biomolecules. A common necroptosis effector—mixed lineage kinase domain like (MLKL)—was recently found to participate in the biogenesis of small and large… read more here.
Keywords: necroptosis associated; necroptosis; evs released; ripk3 mlkl ... See more keywords
VDX‐111, a novel small molecule, induces necroptosis to inhibit ovarian cancer progression
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23721
Abstract: Epithelial ovarian cancers that are nonhomologous recombination deficient, as well as those that are recurrent and in a platinum‐resistant state, have limited therapeutic options. The objectives of this study were to characterize the mechanism of… read more here.
Keywords: vdx 111; ovarian cancer; necroptosis; cell ... See more keywords
Profiling of small-molecule necroptosis inhibitors based on the subpockets of kinase-ligand interactions.
Sign Up to like & getrecommendations! Published in 2023 at "Medicinal research reviews"
DOI: 10.1002/med.21968
Abstract: Necroptosis is a highly regulated cell death (RCD) form in various inflammatory diseases. Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are involved in the pathway. Targeting the kinase domains of RIPK1 and/or 3 is a… read more here.
Keywords: necroptosis; kinase ligand; kinase domains; kinase ... See more keywords
The antagonistic effect of melatonin on TBBPA‐induced apoptosis and necroptosis via PTEN/PI3K/AKT signaling pathway in swine testis cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23595
Abstract: Tetrabromobisphenol A (TBBPA) is a widely used industrial brominated flame retardant, which can endanger animal and human health, including cytotoxicity, endocrine disruption, reproductive toxicity and so on. Melatonin (MT) is a noteworthy free radical scavenger… read more here.
Keywords: necroptosis; pi3k akt; tbbpa; expression ... See more keywords