Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149259
Abstract: Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its halfâlife. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells. Recent data… read more here.
Keywords: properdin binding; alternative pathway; necrotic cells; properdin ... See more keywords
Phase separation in necrotic cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.08.123
Abstract: Necrotic cells are known to develop characteristic membrane blebs. We measured protein concentration within necrotic blebs and found that it can be reduced by as much as twenty-fold compared to the main cell body (CB).… read more here.
Keywords: protein; phase separation; blebs; equilibrium ... See more keywords
Local Necrotic Cells Trigger Systemic Immune Activation via Gut Microbiome Dysbiosis in Drosophila.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107938
Abstract: Necrotic cells elicit an inflammatory response through their endogenous factors with damage-associated molecular patterns. Blocking apoptosis in Drosophila wings leads to the necrosis-driven systemic immune response by unknown mechanisms. Here, we demonstrate that immune activation… read more here.
Keywords: immune activation; response; necrotic cells; systemic immune ... See more keywords
Anti-inflammatory and antiaging properties of chlorogenic acid on UV-induced fibroblast cell
Sign Up to like & getrecommendations! Published in 2021 at "PeerJ"
DOI: 10.7717/peerj.11419
Abstract: Background Skin aging is the most common dermatological problem caused by intrinsic and extrinsic factor, such as exposure to (ultraviolet) UV rays. Chlorogenic acid (CA) is a phenolic compound which is known for its antioxidant… read more here.
Keywords: anti inflammatory; cells col; antiaging properties; necrotic cells ... See more keywords