Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity
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DOI: 10.1136/jitc-2019-000266
Abstract: Background The use of checkpoint inhibitors has revolutionized cancer therapy. Unfortunately, these therapies often cause immune-related adverse effects, largely due to a lack of tumor specificity. Methods We stained human natural killer cells using fusion… read more here.
Keywords: tumor specificity; nectin4 novel; checkpoint; ligand ... See more keywords
NECTIN4: A Novel Therapeutic Target for Melanoma
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DOI: 10.3390/ijms22020976
Abstract: Malignant melanoma is the most common lethal skin cancer and causes death in a short time when metastasized. Although BRAF inhibitors (BRAFi) have greatly improved the prognosis of BRAF-mutated melanoma, drug resistance is a major… read more here.
Keywords: melanoma; nectin4 novel; brafi; brafi resistant ... See more keywords