Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.088
Abstract: The class III phosphoinositide 3-kinase vacuolar protein sorting 34 (VPS34) is a core protein of autophagy initiation, yet the regulatory mechanisms responsible for its stringent control remain poorly understood. Here, we report that the E3… read more here.
Keywords: auto ubiquitination; nedd4; nedd4 recruits; ubiquitination nedd4 ... See more keywords
Proteomic Characterization of NEDD4 Unveils Its Potential Novel Downstream Effectors in Gastric Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.4c01109
Abstract: The E3 ubiquitin ligase neural precursor cell-expressed developmentally down-regulated 4 (NEDD4) is involved in various cancer signaling pathways, including PTEN/AKT. However, its role in promoting gastric cancer (GC) progression is unclear. This study was conducted… read more here.
Keywords: cancer; downstream effectors; gastric cancer; nedd4 ... See more keywords
NEDD4 attenuates phosgene‐induced acute lung injury through the inhibition of Notch1 activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17296
Abstract: Phosgene gas leakage can cause life‐threatening acute lung injury (ALI), which is characterized by inflammation, increased vascular permeability, pulmonary oedema and oxidative stress. Although the downregulation of neuronal precursor cell‐expressed developmentally downregulated 4 (NEDD4) is… read more here.
Keywords: lung; phosgene induced; nedd4; lung injury ... See more keywords
Pharmacological suppression of Nedd4-2 rescues the reduction of Kv11.1 channels in pathological cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.942769
Abstract: The human ether-á-go-go-related gene (hERG) encodes the pore-forming subunit (Kv11.1), conducting a rapidly delayed rectifier K+ current (I Kr). Reduction of I Kr in pathological cardiac hypertrophy (pCH) contributes to increased susceptibility to arrhythmias. However,… read more here.
Keywords: pch; pathological cardiac; nedd4; cardiac hypertrophy ... See more keywords
Serum and Glucocorticoid-Inducible Kinase 3/Nedd4-2 Signaling Pathway Participates in Podocyte Injury by Regulating the Stability of Nephrin
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.810473
Abstract: Serum and glucocorticoid-inducible kinase 3 (SGK3) is involved in maintaining podocyte function by regulating the protein levels of podocin and CD2-associated protein. Nephrin is also one of the slit diaphragm proteins of podocytes, but whether… read more here.
Keywords: nedd4; sgk3; kinase; podocyte injury ... See more keywords
The E3 Ubiquitin Ligase NEDD4-1 Mediates Temozolomide-Resistant Glioblastoma through PTEN Attenuation and Redox Imbalance in Nrf2-HO-1 Axis.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of molecular sciences"
DOI: 10.3390/ijms221910247
Abstract: BACKGROUND Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. It is highly resistant to chemotherapy, and tumor recurrence is common. Neuronal precursor cell-expressed developmentally downregulated 4-1 (NEDD4-1) is an E3 ligase… read more here.
Keywords: glioblastoma; tmz resistant; gbm cells; nedd4 ... See more keywords
NEDD4 enhances bone‑tendon healing in rotator cuff tears by reducing fatty infiltration
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2024.13420
Abstract: Rotator cuff tears (RCT) can cause shoulder pain, weakness and stiffness, significantly affecting daily life. Analysis of the GSE103266 dataset revealed significant changes in the mTOR/PI3K/Akt signaling pathway and lipid metabolism-related pathways, suggesting that fatty… read more here.
Keywords: rotator cuff; nedd4; infiltration; fatty infiltration ... See more keywords
Degrading Seizures (or, Playing Tag with Nedd4-2)
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsy Currents"
DOI: 10.5698/1535-7597.17.4.241
Abstract: Commentary Tightly regulated protein homeostasis is essential for neuronal function. In response to external stimuli, proteins are constantly added to and removed from synapses. The dynamic regulation of synaptic and neuronal protein content is achieved… read more here.
Keywords: protein; epilepsy; nedd4; degrading seizures ... See more keywords