NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-20301-6_19
Abstract: Massively parallel sequencing, genomic and proteomic technologies have provided near complete resolution of signaling landscape of breast cancer (BCa). NEDD4 family of E3-ubiquitin ligases comprises a large family of proteins particularly, SMURFs (SMURF1, SMURF2), WWPs… read more here.
Keywords: breast cancer; wwps; wwps nedd4; cancer ... See more keywords
Allosteric auto‐inhibition and activation of the Nedd4 family E3 ligase Itch
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DOI: 10.15252/embr.201744454
Abstract: The Nedd4 family E3 ligases are key regulators of cell growth and proliferation and are often misregulated in human cancers and other diseases. The ligase activities of Nedd4 E3s are tightly controlled via auto‐inhibition. However,… read more here.
Keywords: auto; itch; auto inhibition; nedd4 family ... See more keywords
Research progress on the role of Ndfip1 (Nedd4 family interacting protein 1) in immune cells.
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DOI: 10.15586/aei.v51i1.739
Abstract: Nedd4 family interacting protein 1 (Ndfip1) was first mentioned in an article in 2000. Since its discovery, related studies have shown that this protein is associated with apoptosis, neuroprotection, substance transport, ubiquitination, and immune regulation.… read more here.
Keywords: role; role ndfip1; nedd4 family; family interacting ... See more keywords
Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3
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DOI: 10.26508/lsa.202101082
Abstract: The NEDD4 family E3 ligase Pub1 is regulated by the nutrient environment, TORC2, and Gsk3 signalling pathway to control the level of amino acid transporters on the plasma membrane and thus nutrient uptake. Cells respond… read more here.
Keywords: nedd4 family; control; gsk3; pub1 ... See more keywords
The regulatory roles of the E3 ubiquitin ligase NEDD4 family in DNA damage response
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DOI: 10.3389/fphys.2022.968927
Abstract: E3 ubiquitin ligases, an important part of ubiquitin proteasome system, catalyze the covalent binding of ubiquitin to target substrates, which plays a role in protein ubiquitination and regulates different biological process. DNA damage response (DDR)… read more here.
Keywords: dna damage; nedd4 family; response;