The Roles of NEDD4 Subfamily of HECT E3 Ubiquitin Ligases in Neurodevelopment and Neurodegeneration
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DOI: 10.3390/ijms23073882
Abstract: The ubiquitin pathway regulates the function of many proteins and controls cellular protein homeostasis. In recent years, it has attracted great interest in neurodevelopmental and neurodegenerative diseases. Here, we have presented the first review on… read more here.
Keywords: nedd4 subfamily; roles nedd4; ligases neurodevelopment; hect ubiquitin ... See more keywords
NEDD4 E3 Ligases: Functions and Mechanisms in Bone and Tooth
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DOI: 10.3390/ijms23179937
Abstract: Protein ubiquitination is a precisely controlled enzymatic cascade reaction belonging to the post-translational modification of proteins. In this process, E3 ligases catalyze the binding of ubiquitin (Ub) to protein substrates and define specificity. The neuronally… read more here.
Keywords: functions mechanisms; nedd4 subfamily; mechanisms bone; bone tooth ... See more keywords