Inhibition of CRL-NEDD8 pathway as a new approach to enhance ATRA-induced differentiation of acute promyelocytic leukemia cells
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DOI: 10.7150/ijms.23782
Abstract: The cullin-RING ligase (CRL)-NEDD8 pathway maintains essential cellular processes, including cell cycle progression, apoptosis, autophagy, DNA repair, antigen processing and signal transduction. Growing evidence demonstrates that the alteration of the CRL-NEDD8 pathway in some cancers… read more here.
Keywords: atra induced; acute promyelocytic; promyelocytic leukemia; nedd8 pathway ... See more keywords