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   Articles with "neddylation" as a keyword



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Neddylation‐CRLs regulate the functions of Treg immune cells

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recommendations! Published in 2023 at "BioEssays"

DOI: 10.1002/bies.202200222

Abstract: Neddylation, a ubiquitylation‐like post‐translational modification, is catalyzed by a cascade composed of three enzymes: E1 activating enzyme, E2 conjugating enzyme, and E3 ligase with cullins as physiological substrates. Specifically, neddylation E2 UBE2M couples with E3… read more here.

Keywords: neddylation; regulate functions; neddylation crls; crls regulate ... See more keywords
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Targeting Protein Neddylation for Cancer Therapy.

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recommendations! Published in 2020 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-981-15-1025-0_18

Abstract: Neddylation is a posttranslational modification that conjugates a ubiquitin-like protein NEDD8 to substrate proteins. The best-characterized substrates of neddylation are the cullin subunits of cullin-RING E3 ubiquitin ligase complexes (CRLs). CRLs as the largest family… read more here.

Keywords: neddylation cancer; targeting protein; protein neddylation; neddylation ... See more keywords
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Blocking neddylation elicits antiviral effect against hepatitis B virus replication.

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recommendations! Published in 2021 at "Molecular biology reports"

DOI: 10.1007/s11033-021-06886-w

Abstract: BACKGROUND Hepatitis B Virus (HBV) is the most common cause of chronic liver disease worldwide. The mechanisms that regulate HBV viral replication remain poorly defined. Here, we show that blocking of the neddylation elicits antiviral… read more here.

Keywords: hbv; neddylation; blocking neddylation; hepatitis virus ... See more keywords
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Neddylation promotes protein translocation between the cytoplasm and nucleus.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.07.012

Abstract: Neddylation is an ubiquitin-like modification of proteins that affects the activity, stability and protein-protein interaction of its substrates. Apart from its role as a promoter for Cullin ring E3 ligase to positively regulate the ubiquitylation… read more here.

Keywords: cytoplasm nucleus; promotes protein; neddylation; protein translocation ... See more keywords
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Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.

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recommendations! Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2020.108635

Abstract: The ubiquitin-like molecule NEDD8 controls several biological processes and is a promising target for therapeutic intervention. NEDDylation occurs through specific NEDD8 enzymes (canonical) or enzymes of the ubiquitin system (atypical). Identification of NEDD8 sites on… read more here.

Keywords: distinct proteomes; neddylation; canonical atypical; atypical neddylation ... See more keywords
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UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F.

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recommendations! Published in 2018 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.06.002

Abstract: UBE2M and UBE2F are two family members of neddylation E2 conjugating enzyme that, together with E3s, activate CRLs (Cullin-RING Ligases) by catalyzing cullin neddylation. However, whether and how two E2s cross-talk with each other are… read more here.

Keywords: degradation; neddylation; ube2m stress; stress inducible ... See more keywords
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Neddylation activity modulates the neurodegeneration associated with fragile X associated tremor/ataxia syndrome (FXTAS) through regulating Sima

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recommendations! Published in 2020 at "Neurobiology of Disease"

DOI: 10.1016/j.nbd.2020.105013

Abstract: Fragile X associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by expansion of CGG repeats in the 5' UTR of the fragile X mental retardation 1 (FMR1) gene. Using the well-established FXTAS Drosophila… read more here.

Keywords: fragile associated; tremor ataxia; associated tremor; ataxia syndrome ... See more keywords
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NEDD8-its role in the regulation of Cullin-RING ligases.

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recommendations! Published in 2018 at "Current opinion in plant biology"

DOI: 10.1016/j.pbi.2018.05.017

Abstract: The ubiquitin-related protein NEDD8 is conjugated and deconjugated to and from proteins in processes related to ubiquitin conjugation and deconjugation. Neddylation is a well-studied posttranslational modification of Cullin-RING E3 ligases (CRLs). Biochemical and structural studies… read more here.

Keywords: cullin ring; ring ligases; cullin; neddylation ... See more keywords
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Effects of Neddylation and mTOR Inhibition in Acute Myelogenous Leukemia

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recommendations! Published in 2019 at "Translational Oncology"

DOI: 10.1016/j.tranon.2019.01.001

Abstract: Acute myelogenous leukemia (AML) is a heterogeneous disease and often relapses after standard chemotherapy. Recently, the neddylation (NEDD8) and the mammalian target of rapamycin (mTOR) signaling pathways have emerged as promising pharmaceutical targets for AML… read more here.

Keywords: acute myelogenous; inhibition; neddylation; mtor ... See more keywords
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Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation

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recommendations! Published in 2021 at "Leukemia"

DOI: 10.1038/s41375-021-01184-7

Abstract: Chronic lymphocytic leukemia (CLL) has focused a strong research effort over the last years due to its high incidence, that will likely increase due to the progressive ageing of the population, and the lack of… read more here.

Keywords: cll; post translational; neddylation; translational modifications ... See more keywords

NEDD8-conjugating enzyme UBC12 as a novel therapeutic target in esophageal squamous cell carcinoma

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recommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-020-00226-3

Abstract: Dear Editor, Esophageal squamous cell carcinoma (ESCC) is the major histologic subtype of esophageal cancer with high incidence and mortality. However, few achievements have been made in the development of targeted drugs. Neddylation, a reversible… read more here.

Keywords: neddylation; ubc12 knockdown; downregulation; fig ... See more keywords