Film Forming Nanogels for Needle-free Transdermal Vaccination.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100515
Abstract: Transcutaneous immunization (TCI) provides a valuable alternative approach to conventional vaccination because of the high accessibility and the exceptional immunological characteristics of the skin, but its application is limited by the low permeability of the… read more here.
Keywords: vaccination; forming nanogels; film forming; needle free ... See more keywords
The effect of pre-anesthesia with a needle-free system versus topical anesthesia on injection pain of the inferior alveolar nerve block: a randomized clinical trial
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-020-03301-9
Abstract: Objective The aim of this study was to compare the effectiveness of pain control between a needle-free system and topical anesthesia applied prior to inferior alveolar nerve block (IANB). Materials and methods The present study… read more here.
Keywords: needle free; anesthesia; injection; free system ... See more keywords
Evaluating the effectiveness of a novel atomized liquid needle-free transdermal delivery system
Sign Up to like & getrecommendations! Published in 2017 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-017-0382-7
Abstract: Needle-free jet injections constitute a crucial method for drug delivery. A novel liquid drug delivery system has been proposed recently, in which pressure atomizes liquid before delivering that atomized liquid to the patient’s body; however,… read more here.
Keywords: needle free; system; delivery system; penetration ... See more keywords
Concentrations and nitrogen isotope compositions of free amino acids in Pinus massoniana (Lamb.) needles of different ages as indicators of atmospheric nitrogen pollution
Sign Up to like & getrecommendations! Published in 2017 at "Atmospheric Environment"
DOI: 10.1016/j.atmosenv.2017.06.024
Abstract: Abstract Free amino acid δ 15 N values and concentrations of current-year new (new), current-year mature (middle-age) and previous-year (old) Pinus massoniana (Lamb.) needles were determined for five sites with different distances from a highway… read more here.
Keywords: needle free; amino; amino acid; acid values ... See more keywords
Impact of the mechanical properties of penetrated media on the injection characteristics of needle-free jet injection
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Thermal and Fluid Science"
DOI: 10.1016/j.expthermflusci.2021.110396
Abstract: Abstract Needle-free jet injection systems are characterized by the increased drug delivery efficacy over conventional needle-based injection systems and have become a viable alternative. The majority of previous studies have investigated underlying mechanisms of needle-free… read more here.
Keywords: jet injection; injection; needle free; fluid ... See more keywords
Feasibility of laser induced jets in needle free jet injections.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2020.119714
Abstract: This paper reports a detailed characterization of laser-induced micro-jets, including ex vivo experiments using skin as a target substrate to check the feasibility in terms of needle-free jet injection. The actuation technique comprised a Nd-YAG… read more here.
Keywords: needle free; laser; free jet; jet ... See more keywords
Characterization of jets for impulsively-started needle-free jet injectors: Influence of fluid properties
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.101167
Abstract: Abstract An experimental study was performed to assess the hydrodynamics of liquid jets used for needle-free injection, where the typical orifice diameter is ~155 μm and velocity is in range of ~ 60–140 m/s. The jet is… read more here.
Keywords: characterization jets; started needle; impulsively started; jet ... See more keywords
A Mathematical Model and Experimental Verification of Optimal Nozzle Diameter in Needle-Free Injection.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.12.001
Abstract: Needle-free injection (NFI), as an alternative drug delivery strategy, owns great potential. It is able to reduce complaints about needle phobia and avoid the occurring of accidental needle stick injuries. The nozzle diameter is inherently… read more here.
Keywords: needle free; mathematical model; nozzle diameter; injection ... See more keywords
HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08739-4
Abstract: The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous epithelium limits antigen uptake. Here we utilize a modified needle-free injector to deliver immunizations to the sublingual and buccal (SL/B) tissue… read more here.
Keywords: needle free; vaccination; igg responses; mucosal immunity ... See more keywords
Induction of potent antitumor immunity by intradermal DNA injection using a novel needle‐free pyro‐drive jet injector
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15542
Abstract: The current success of mRNA vaccines against COVID‐19 has highlighted the effectiveness of mRNA and DNA vaccinations. Recently, we demonstrated that a novel needle‐free pyro‐drive jet injector (PJI) effectively delivers plasmid DNA into the skin,… read more here.
Keywords: injection; dna; needle free; ova specific ... See more keywords
Needle-free devices: keeping the system closed.
Sign Up to like & getrecommendations! Published in 2017 at "British journal of nursing"
DOI: 10.12968/bjon.2017.26.2.s14
Abstract: Health professionals are under increasing pressure to reduce costs while ensuring patient safety. As the number of vascular access devices (VADs) used in health care continues to increase, there is a need to reduce the… read more here.
Keywords: needle free; devices keeping; keeping system; free devices ... See more keywords