DIAGNOSING CARDIAC SARCOIDOSIS: FINDING THE NEEDLE IN THE HAYSTACK
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)33398-4
Abstract: The Expert Consensus Recommendations on Criteria for the Diagnosis of Cardiac Sarcoidosis (CS) require histological evidence of non-caseating granulomas. However, the disease's patchy myocardial involvement limits the diagnostic yield of blind endomyocardial biopsies (EMB). A… read more here.
Keywords: sarcoidosis; cardiac sarcoidosis; finding needle; sarcoidosis finding ... See more keywords
Magnet for the Needle in Haystack: "Crystal Structure First" Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical Spaces.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00813
Abstract: Fragment-based drug discovery (FBDD) has successfully led to approved therapeutics for challenging and "undruggable" targets. In the context of FBDD, we introduce a novel, multidisciplinary method to identify active molecules from purchasable chemical space. Starting… read more here.
Keywords: structure first; magnet needle; chemical; haystack crystal ... See more keywords
Finding a Needle in a Haystack: Producing Antimicrobial Cutin-Derived Oligomers from Tomato Pomace
Sign Up to like & getrecommendations! Published in 2022 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.2c03437
Abstract: Agro-industrial residues comprise a rich diversity of plant polymers and bioactive compounds, constituting promising sources for the development of materials, including bioplastics, and food supplements, among other applications. In particular, the polyester cutin is abundant… read more here.
Keywords: finding needle; cutin; cutin derived; pomace ... See more keywords
The needle and the haystack: single molecule tracking to probe the transcription factor search in eukaryotes
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society Transactions"
DOI: 10.1042/bst20200709
Abstract: Transcription factors (TFs) regulate transcription of their target genes by identifying and binding to regulatory regions of the genome among billions of potential non-specific decoy sites, a task that is often presented as a ‘needle… read more here.
Keywords: single molecule; transcription; molecule tracking; needle haystack ... See more keywords
Finding the Needle in a Haystack: Detrending Photometric Timeseries Data of Strictly Periodic Astrophysical Objects
Sign Up to like & getrecommendations! Published in 2019 at "Publications of the Astronomical Society of the Pacific"
DOI: 10.1088/1538-3873/ab0f41
Abstract: Light curves of astrophysical objects frequently contain strictly periodic signals. In those cases we can use that property to aid the detrending algorithm to fully disentangle an unknown periodic signal and an unknown baseline signal… read more here.
Keywords: finding needle; strictly periodic; haystack detrending; periodic signal ... See more keywords
Late relapses in Hodgkin lymphoma – should we search for the needle in the haystack?
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18199
Abstract: Hodgkin lymphoma is among the most curable cancers. For patients in remission for 24 months, residual lifetime becomes close to that of the background population. However, late relapses can occur after several years and, as shown… read more here.
Keywords: relapses hodgkin; hodgkin lymphoma; lymphoma search; late relapses ... See more keywords
Finding the needle in the haystack: the diagnostic accuracy of the faecal immunochemical test for colorectal cancer in younger symptomatic patients
Sign Up to like & getrecommendations! Published in 2021 at "Colorectal Disease"
DOI: 10.1111/codi.15786
Abstract: Detection of early onset colorectal cancer is challenging, and remains a rare diagnosis amongst younger people with gastrointestinal symptoms. We investigated whether faecal immunochemical testing (FIT) could identify younger patients at higher risk of colorectal… read more here.
Keywords: finding needle; faecal immunochemical; colorectal cancer; needle haystack ... See more keywords
Finding the needle in the haystack is teledermoscopy's task
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.14699
Abstract: We read with interest the recent letter in this journal by Kukutsch et al. as to the opinion of an international group of experts on dermoscopy about the practice of teledermoscopy (TDC) between primary care physicians… read more here.
Keywords: finding needle; teledermoscopy; dermatology; haystack teledermoscopy ... See more keywords
Finding a needle in a haystack: Bacteroides fragilis polysaccharide A as the archetypical symbiosis factor
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.13660
Abstract: Starting from birth, all animals develop a symbiotic relationship with their resident microorganisms that benefits both the microbe and the host. Recent advances in technology have substantially improved our ability to direct research toward the… read more here.
Keywords: finding needle; bacteroides fragilis; needle haystack; polysaccharide archetypical ... See more keywords
Finding the needle in a haystack: Mapping antifungal drug resistance in fungal pathogen by genomic approaches
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007478
Abstract: Fungi are ubiquitous on earth and are essential for the maintenance of the global ecological equilibrium. Despite providing benefits to living organisms, they can also target specific hosts and inflict damage. These fungal pathogens are… read more here.
Keywords: antifungal agents; finding needle; fungal pathogens; drug ... See more keywords
Needle in a Haystack: The Naïve Repertoire as a Source of T Cell Receptors for Adoptive Therapy with Engineered T Cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21218324
Abstract: T cell engineering with antigen-specific T cell receptors (TCRs) has allowed the generation of increasingly specific, reliable, and versatile T cell products with near-physiological features. However, a broad applicability of TCR-based therapies in cancer is… read more here.
Keywords: needle haystack; cell receptors; repertoire; therapy ... See more keywords