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   Articles with "needle haystack" as a keyword



DIAGNOSING CARDIAC SARCOIDOSIS: FINDING THE NEEDLE IN THE HAYSTACK

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recommendations! Published in 2019 at "Journal of the American College of Cardiology"

DOI: 10.1016/s0735-1097(19)33398-4

Abstract: The Expert Consensus Recommendations on Criteria for the Diagnosis of Cardiac Sarcoidosis (CS) require histological evidence of non-caseating granulomas. However, the disease's patchy myocardial involvement limits the diagnostic yield of blind endomyocardial biopsies (EMB). A… read more here.

Keywords: sarcoidosis; cardiac sarcoidosis; finding needle; sarcoidosis finding ... See more keywords

Magnet for the Needle in Haystack: "Crystal Structure First" Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical Spaces.

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recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c00813

Abstract: Fragment-based drug discovery (FBDD) has successfully led to approved therapeutics for challenging and "undruggable" targets. In the context of FBDD, we introduce a novel, multidisciplinary method to identify active molecules from purchasable chemical space. Starting… read more here.

Keywords: structure first; magnet needle; chemical; haystack crystal ... See more keywords

Finding a Needle in a Haystack: Producing Antimicrobial Cutin-Derived Oligomers from Tomato Pomace

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recommendations! Published in 2022 at "ACS Sustainable Chemistry & Engineering"

DOI: 10.1021/acssuschemeng.2c03437

Abstract: Agro-industrial residues comprise a rich diversity of plant polymers and bioactive compounds, constituting promising sources for the development of materials, including bioplastics, and food supplements, among other applications. In particular, the polyester cutin is abundant… read more here.

Keywords: finding needle; cutin; cutin derived; pomace ... See more keywords

The needle and the haystack: single molecule tracking to probe the transcription factor search in eukaryotes

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recommendations! Published in 2021 at "Biochemical Society Transactions"

DOI: 10.1042/bst20200709

Abstract: Transcription factors (TFs) regulate transcription of their target genes by identifying and binding to regulatory regions of the genome among billions of potential non-specific decoy sites, a task that is often presented as a ‘needle… read more here.

Keywords: single molecule; transcription; molecule tracking; needle haystack ... See more keywords

Finding the needle in the haystack of isokinetic knee data: Random Forest modelling improves information about ACLR-related deficiencies

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recommendations! Published in 2024 at "Journal of Sports Sciences"

DOI: 10.1080/02640414.2024.2435729

Abstract: ABSTRACT The difficulties of rehabilitation after anterior cruciate ligament (ACL) injuries, subsequent return-to-sport (RTS) let alone achieving pre-injury performance, are well known. Isokinetic testing is often used to assess strength capacities during that process. The… read more here.

Keywords: haystack isokinetic; random forest; finding needle; isokinetic knee ... See more keywords
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Finding the Needle in a Haystack: Detrending Photometric Timeseries Data of Strictly Periodic Astrophysical Objects

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recommendations! Published in 2019 at "Publications of the Astronomical Society of the Pacific"

DOI: 10.1088/1538-3873/ab0f41

Abstract: Light curves of astrophysical objects frequently contain strictly periodic signals. In those cases we can use that property to aid the detrending algorithm to fully disentangle an unknown periodic signal and an unknown baseline signal… read more here.

Keywords: finding needle; strictly periodic; haystack detrending; periodic signal ... See more keywords

Late relapses in Hodgkin lymphoma – should we search for the needle in the haystack?

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recommendations! Published in 2022 at "British Journal of Haematology"

DOI: 10.1111/bjh.18199

Abstract: Hodgkin lymphoma is among the most curable cancers. For patients in remission for 24 months, residual lifetime becomes close to that of the background population. However, late relapses can occur after several years and, as shown… read more here.

Keywords: relapses hodgkin; hodgkin lymphoma; lymphoma search; late relapses ... See more keywords
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Finding the needle in the haystack: the diagnostic accuracy of the faecal immunochemical test for colorectal cancer in younger symptomatic patients

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recommendations! Published in 2021 at "Colorectal Disease"

DOI: 10.1111/codi.15786

Abstract: Detection of early onset colorectal cancer is challenging, and remains a rare diagnosis amongst younger people with gastrointestinal symptoms. We investigated whether faecal immunochemical testing (FIT) could identify younger patients at higher risk of colorectal… read more here.

Keywords: finding needle; faecal immunochemical; colorectal cancer; needle haystack ... See more keywords
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Finding the needle in the haystack is teledermoscopy's task

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recommendations! Published in 2018 at "Journal of the European Academy of Dermatology and Venereology"

DOI: 10.1111/jdv.14699

Abstract: We read with interest the recent letter in this journal by Kukutsch et al. as to the opinion of an international group of experts on dermoscopy about the practice of teledermoscopy (TDC) between primary care physicians… read more here.

Keywords: finding needle; teledermoscopy; dermatology; haystack teledermoscopy ... See more keywords
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Finding a needle in a haystack: Bacteroides fragilis polysaccharide A as the archetypical symbiosis factor

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recommendations! Published in 2018 at "Annals of the New York Academy of Sciences"

DOI: 10.1111/nyas.13660

Abstract: Starting from birth, all animals develop a symbiotic relationship with their resident microorganisms that benefits both the microbe and the host. Recent advances in technology have substantially improved our ability to direct research toward the… read more here.

Keywords: finding needle; bacteroides fragilis; needle haystack; polysaccharide archetypical ... See more keywords

Needle in a haystack: Harnessing AI in drug patent searches and prediction

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recommendations! Published in 2024 at "PLOS ONE"

DOI: 10.1371/journal.pone.0311238

Abstract: The classification codes granted by patent offices are useful instruments for simplifying the bewildering variety of patents in existence. They are singularly unhelpful, however, in locating a specific subgroup of patents such as that of… read more here.

Keywords: harnessing drug; haystack harnessing; drug; patent ... See more keywords