Consequences of HLA‐associated mutations in HIV‐1 subtype C Nef on HLA‐I downregulation ability
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DOI: 10.1002/jmv.25676
Abstract: Identification of CD8+ T lymphocyte (CTL) escape mutations that compromise the pathogenic functions of the Nef protein may be relevant for an HIV‐1 attenuation‐based vaccine. Previously, HLA‐associated mutations 102H, 105R, 108D, and 199Y were individually… read more here.
Keywords: hla downregulation; downregulation ability; downregulation; nef ... See more keywords
HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00196-18
Abstract: ABSTRACT The primate lentiviral accessory protein Nef downregulates CD4 and major histocompatibility complex class I (MHC-I) from the cell surface via independent endosomal trafficking pathways to promote viral pathogenesis. In addition, Nef antagonizes a novel… read more here.
Keywords: restriction; ser5; downregulation; nef ... See more keywords