Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.02.011
Abstract: Functional characterisation of different HIV-1 subtypes may improve understanding of viral pathogenesis and spread. Here, we evaluated the ability of 345 unique HIV-1 Nef clones representing subtypes A, B, C and D to inhibit NFAT… read more here.
Keywords: nef clones; nef mediated; tcr stimulation; hiv subtypes ... See more keywords
Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3
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DOI: 10.1038/s41467-017-00481-z
Abstract: Lentiviral Nefs recruit assembly polypeptide complexes and target sorting motifs in cellular receptors to induce their internalization. While Nef-mediated CD4 downmodulation is conserved, the ability to internalize CD3 was lost in HIV-1 and its precursors.… read more here.
Keywords: cd3; nef mediated; motif interactions; sorting motif ... See more keywords
Two Functional Variants of AP-1 Complexes Composed of either γ2 or γ1 Subunits Are Independently Required for Major Histocompatibility Complex Class I Downregulation by HIV-1 Nef
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.02039-19
Abstract: HIV-1 Nef mediates evasion of the host immune system by inhibiting MHC-I surface presentation of viral antigens. To achieve this goal, Nef modifies the intracellular trafficking of MHC-I molecules in several ways. Despite being the… read more here.
Keywords: hla; mhc; nef mediated; downregulation ... See more keywords