Negating coordinative cysteine and methionine residues during metathesis of unprotected peptides.
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DOI: 10.1039/d3cc01476b
Abstract: Ru-Alkylidene catalysed olefin metathesis generates metabolically stable cystine bridge peptidomimetics with defined geometry. Deleterious coordinative bonding to the catalyst by sulfur-containing functionality found in cysteine and methionine residues can be negated by in situ and… read more here.
Keywords: methionine residues; coordinative cysteine; metathesis; cysteine methionine ... See more keywords