A mouse model of Proteus syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz116
Abstract: Proteus syndrome is a mosaic, progressive overgrowth disorder caused by a somatic activating variant c.49G>A p.(E17K) in AKT1. The presentation in affected individuals is variable, with a diversity of tissues demonstrating abnormalities. Common manifestations include… read more here.
Keywords: proteus syndrome; negative cells; syndrome mice; gfp akt1e17k ... See more keywords
Double‐negative T cells: Setting the stage for disease control or progression
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1111/imm.13441
Abstract: Double‐negative (DN) T cells are present at relatively low frequencies in human peripheral blood, and are characterized as expressing the alpha‐beta or gamma‐delta T‐cell receptor (TCR), but not the CD4 nor the CD8 co‐receptors. Despite… read more here.
Keywords: negative cells; double negative; setting stage; cells setting ... See more keywords
Double-Negative T Cells Attenuate Cisplatin-Induced Acute Kidney Injury via Upregulating IL-10/AT2R Axis
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/3629373
Abstract: Objective Our previous research showed that TCR+CD4-CD8-double-negative (DN) T cells protect renal epithelial cells from cisplatin-induced acute kidney injury (AKI). Therefore, this study is aimed at investigating the mechanism underlying the effect of DN T… read more here.
Keywords: double negative; induced acute; injury; cisplatin induced ... See more keywords
Application of double-negative T cells in haematological malignancies: recent progress and future directions
Sign Up to like & getrecommendations! Published in 2022 at "Biomarker Research"
DOI: 10.1186/s40364-022-00360-w
Abstract: Haematologic malignancies account for a large proportion of cancers worldwide. The high occurrence and mortality of haematologic malignancies create a heavy social burden. Allogeneic haematopoietic stem cell transplantation is widely used in the treatment of… read more here.
Keywords: negative cells; double negative; cell; versus host ... See more keywords
The potential target of double negative T cells in cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15180
Abstract: e15180Background: Double negative T cell (DNT) is defined by the expression of CD3 (or TCRαβ) with the absence of CD4, CD8 and iNKT cell markers. DNTs account for 1-3% of the total peripheral lymph... read more here.
Keywords: potential target; negative cells; cells cancer; double negative ... See more keywords
Activation and Proliferation of PD-1+ Kidney Double-Negative T Cells Is Dependent on Nonclassical MHC Proteins and IL-2.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2018080815
Abstract: BACKGROUND CD4- CD8- double-negative (DN) αβ T cells with innate-like properties represent a significant component of T cells in human and mouse kidneys. They spontaneously proliferate in the steady state and protect against ischemic AKI.… read more here.
Keywords: negative cells; double negative; activation proliferation; kidney ... See more keywords
Phenotypic and Functional Characterization of Double Negative B Cells in the Blood of Individuals With Obesity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.616650
Abstract: We have previously shown that obesity is associated with increased secretion of IgG antibodies with anti-self-reactivity. In this paper, we confirm and extend our previous findings. We show that the plasma of individuals with obesity… read more here.
Keywords: negative cells; individuals obesity; double negative; blood ... See more keywords