Dichotomous Nature of Bistability Generated by Negative Cooperativity in Receptor-Ligand Binding.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00517
Abstract: Positive cooperativity in receptor-ligand binding plays an important role in cell signaling as it generates an ultrasensitive response, a requirement for nonlinear phenomena such as bistability and oscillations in feedback regulated reaction networks. On the… read more here.
Keywords: receptor ligand; negative cooperativity; bistability; cooperativity ... See more keywords
FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0169
Abstract: Cardiac ryanodine receptors (RyR2) release the Ca2+ from intracellular stores that is essential for cardiac myocyte contraction. The ion channel opening is tightly regulated by intracellular factors, including the FK506 binding proteins, FKBP12 and FKBP12.6.… read more here.
Keywords: physiology; fkbp12; negative cooperativity; cardiac ryanodine ... See more keywords