Targeting the Negative Feedback of Adenosine-A2AR Metabolic Pathway by a Tailored Nanoinhibitor for Photothermal Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104182
Abstract: The metabolite adenosine plays an important immunosuppressive role in the tumor microenvironment (TME) through its ligation with the metabolic checkpoint adenosine 2A receptor (A2AR). Here, an adenosine-A2AR negative feedback pathway is highlighted during photothermal-induced immunogenic… read more here.
Keywords: tumor; adenosine a2ar; a2ar metabolic; negative feedback ... See more keywords
Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport Flow in a Cellular Negative Feedback Loop
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201414
Abstract: Bile acid‐modified nanoparticles provide a convenient strategy to improve oral bioavailability of poorly permeable drugs by exploiting specific interactions with bile acid transporters. However, the underlying mechanisms are unknown, especially considering the different absorption sites… read more here.
Keywords: acid; transport; negative feedback; conjugation ... See more keywords
Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03601-z
Abstract: Polysialic acid (polySia) emerges as a novel regulator of microglia activity. We recently identified polysialylated proteins in the Golgi compartment of murine microglia that are released in response to inflammatory stimulation. Since exogenously added polySia… read more here.
Keywords: siglec; polysialic acid; response; polysia ... See more keywords
A Meta-Analysis of Negative Feedback on Intrinsic Motivation
Sign Up to like & getrecommendations! Published in 2019 at "Educational Psychology Review"
DOI: 10.1007/s10648-018-9446-6
Abstract: The most prominent view in psychological theory has been that negative feedback should generally have a detrimental impact on intrinsic motivation. Competing perspectives and caveats on this view have suggested that negative feedback may sometimes… read more here.
Keywords: negative feedback; intrinsic motivation; feedback; feedback intrinsic ... See more keywords
Delayed feedback induced complex dynamics in an Escherichia coli and Tetrahymena system
Sign Up to like & getrecommendations! Published in 2018 at "Nonlinear Dynamics"
DOI: 10.1007/s11071-018-4434-4
Abstract: Abundances of bacterial species such as Escherichia coli in a given environment are partly regulated by predation by protozoa species. Interactions among prey and predator species are not simple since a prey species has acquired… read more here.
Keywords: delayed feedback; escherichia coli; feedback; predator ... See more keywords
Attentional bias of students toward negative feedback in bad outcome situations: the mechanism of self-defense
Sign Up to like & getrecommendations! Published in 2018 at "Social Psychology of Education"
DOI: 10.1007/s11218-018-9429-y
Abstract: The main goals of the present study were to investigate the effects of outcome valence on attentional bias toward feedback and examine the internal mechanism of self-defense. We systematically manipulated the outcome valence by providing… read more here.
Keywords: bad outcome; feedback; self defense; outcome situations ... See more keywords
The Microtubule-Associated Protein CLASP Sustains Cell Proliferation through a Brassinosteroid Signaling Negative Feedback Loop
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.06.048
Abstract: The capacity for sustained cell division within the plant meristem is a critical determinant of organ structure and performance. This capacity is diminished in mutants lacking the microtubule-associated protein CLASP and when brassinosteroid signaling is… read more here.
Keywords: associated protein; clasp; microtubule associated; brassinosteroid signaling ... See more keywords
An impulsive model of endocrine regulation with two negative feedback loops
Sign Up to like & getrecommendations! Published in 2017 at "IFAC-PapersOnLine"
DOI: 10.1016/j.ifacol.2017.08.2508
Abstract: Whereas obtaining a global model of the human endocrine system remains a challenging problem, visible progress has been demonstrated in modeling its subsystems (axes) that regulate production of specific hormones. The axes are typically described… read more here.
Keywords: feedback loops; feedback; endocrine regulation; model ... See more keywords
Evidence of a negative feedback network between TDP-43 and miRNAs dependent on TDP-43 nuclear localization.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.10.029
Abstract: TAR DNA-binding protein 43 (TDP-43) is a DNA/RNA-binding protein that is integral to RNA processing. Among these functions is a critical role in microRNA (miRNA) biogenesis through interactions with the DROSHA and DICER complexes. It… read more here.
Keywords: tdp; nuclear localization; feedback network; negative feedback ... See more keywords
FKBP5 polymorphisms and hypothalamic-pituitary-adrenal axis negative feedback in major depression and obsessive-compulsive disorder.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2018.08.003
Abstract: Major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) have both been linked to abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. Polymorphisms in the genes involved in HPA axis activity, such as FKBP5, and their interactions with… read more here.
Keywords: axis; negative feedback; disorder; axis negative ... See more keywords
Negative feedback regulation of thyrotropin subunits and pituitary deiodinases in red drum, Sciaenops ocellatus.
Sign Up to like & getrecommendations! Published in 2017 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2016.09.003
Abstract: Thyroxine (T4) undergoes dynamic daily cycles in the perciform fish the red drum, Sciaenops ocellatus, that are inversely timed to cycles of thyrotropin (TSH) subunit mRNA expression in the pituitary gland. We have proposed that… read more here.
Keywords: feedback; sciaenops ocellatus; expression; red drum ... See more keywords