Tamoxifen administration induces histopathologic changes within the lungs of Cre-recombinase-negative mice: A case report.
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DOI: 10.1177/00236772211042968
Abstract: Tamoxifen is commonly used as a cancer treatment in humans and for inducing genetic alterations using Cre-lox mouse models in the research setting. However, the extent of tamoxifen off-target effects in animal research is underappreciated.… read more here.
Keywords: recombinase negative; negative mice; tamoxifen; cre recombinase ... See more keywords