Peripheral Aβ acts as a negative modulator of insulin secretion
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117723119
Abstract: Significance The cerebral accumulation of amyloid β (Aβ) is a hallmark of Alzheimer’s disease (AD). While type 2 diabetes mellitus is known to be a risk factor for AD, the underlying mechanisms remain unclear. In… read more here.
Keywords: negative modulator; acts negative; insulin secretion; peripheral acts ... See more keywords
Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.662227
Abstract: Lypd6 is a GPI-tethered protein from the Ly-6/uPAR family expressed in the brain. Lypd6 enhances the Wnt/β-catenin signaling, although its action on nicotinic acetylcholine receptors (nAChRs) have been also proposed. To investigate a cholinergic activity… read more here.
Keywords: negative modulator; protein lypd6; brain; three finger ... See more keywords