CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation.
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DOI: 10.1016/j.canlet.2016.10.033
Abstract: With the discovery of the CRISPR/Cas9 technology, genome editing could be performed in a rapid, precise and effective manner. Its potential applications in functional interrogation of cancer-causing genes and cancer therapy have been extensively explored.… read more here.
Keywords: crispr; dominant negative; negative mutation; cancer ... See more keywords