Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
Sign Up to like & getrecommendations! Published in 2018 at "Hematology, Transfusion and Cell Therapy"
DOI: 10.1016/j.htct.2017.12.003
Abstract: Background Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms. Methods This study examined the plasma cytokine profiles… read more here.
Keywords: neoplasms disorders; philadelphia negative; primary myelofibrosis; negative myeloproliferative ... See more keywords
Quantitative assessment of JAK2 V617F and CALR mutations in Philadelphia negative myeloproliferative neoplasms.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.12.005
Abstract: BACKGROUND Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent mutations of driver genes including JAK2, CALR and MPL. While the influence of JAK2 V617F mutant allele burden on the clinical phenotype of MPN patients… read more here.
Keywords: philadelphia negative; negative myeloproliferative; calr; calr mutations ... See more keywords
The immune landscape in BCR-ABL negative myeloproliferative neoplasms: inflammation, infections and opportunities for immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of haematology"
DOI: 10.1111/bjh.17850
Abstract: Breakpoint cluster region-Abelson (BCR-ABL) negative myeloproliferative neoplasms (MPNs) are chronic myeloid neoplasms initiated by the acquisition of gene mutation(s) in a haematopoietic stem cell, leading to clonal expansion and over-production of blood cells and their… read more here.
Keywords: negative myeloproliferative; inflammation; bcr abl; abl negative ... See more keywords
Second malignancies in hydroxyurea and interferon‐treated Philadelphia‐negative myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Haematology"
DOI: 10.1111/ejh.12787
Abstract: In an era of controversy in regard to ‘hydroxyurea‐leukaemogenicity’ and when interferon‐alfa2 (IFN) is being revived in the treatment of Philadelphia‐negative myeloproliferative neoplasms (MPNs), we aim in this single‐centre observational study to describe the frequencies… read more here.
Keywords: second malignancies; philadelphia negative; negative myeloproliferative; hydroxyurea interferon ... See more keywords
Characteristics and outcomes of young adults with Philadelphia‐negative myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Haematology"
DOI: 10.1111/ejh.13232
Abstract: Approximately 10% of Philadelphia (Ph)‐negative myeloproliferative neoplasms (NPM) are diagnosed at young adulthood. We aim to define the features of this group. read more here.
Keywords: philadelphia negative; negative myeloproliferative; characteristics outcomes; outcomes young ... See more keywords
Splenic Infarction in Patients with Philadelphia-negative Myeloproliferative Neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine"
DOI: 10.2169/internalmedicine.9124-21
Abstract: Objective We retrospectively analyzed the prevalence and clinical features of splenic infarctions in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (Ph- MPNs). Patients Patients diagnosed with essential thrombocythemia (ET), polycythemia vera (PV), prefibrotic/early primary myelofibrosis (pre-PMF),… read more here.
Keywords: pmf; patients philadelphia; pre pmf; splenic infarctions ... See more keywords
Methylation of the suppressor of Cytokine Signaling 1 Gene (SOCS1) in Philadelphia-negative myeloproliferative neoplasms.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202211_30381
Abstract: OBJECTIVE Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway activation is initiated by mutations in the JAK2 gene. This activation is in turn, a vital pathogenetic mechanism in myeloproliferative neoplasms (MPNs). However, several factors… read more here.
Keywords: jak stat; methylation; philadelphia negative; cytokine signaling ... See more keywords
JAK2, CALR, MPL and ASXL1 mutational status correlates with distinct histological features in Philadelphia chromosome-negative myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2017.178988
Abstract: Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPN) [essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF)] vary in morphological features, disease presentation, and, most importantly, clinical outcome.[1][1] The World Health Organization (WHO) read more here.
Keywords: negative myeloproliferative; jak2 calr; philadelphia chromosome; myeloproliferative neoplasms ... See more keywords
Ocular Manifestations in Patients with Philadelphia-Negative Myeloproliferative Neoplasms
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12030573
Abstract: The major complications of Philadelphia-negative (Ph-Negative) myeloproliferative neoplasms (MPNs) are thrombosis, haemorrhage and leukemic transformation. As systemic and haematological diseases, MPNs have the potential to affect many tissues and organs. Some complications lead to the… read more here.
Keywords: ocular manifestations; philadelphia negative; negative myeloproliferative; patients philadelphia ... See more keywords
Health-Related Quality of Life in Patients with Philadelphia-Negative Myeloproliferative Neoplasms: A Nationwide Population-Based Survey in Denmark
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12123565
Abstract: Simple Summary The aim of this research was to investigate the health-related quality of life (HRQoL) in patients with Philadelphia-negative myeloproliferative neoplasms (chronic blood cancers) in Denmark. A nationwide questionnaire survey covering functioning, symptom burden,… read more here.
Keywords: philadelphia negative; negative myeloproliferative; survey; myeloproliferative neoplasms ... See more keywords
The Genomic Landscape in Philadelphia-Negative Myeloproliferative Neoplasm Patients with Second Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14143435
Abstract: Simple Summary Philadelphia-chromosome-negative myeloproliferative neoplasms (MPNs) are a group of clonal hematopoietic stem cell disorders characterized by the excessive production of differentiated myeloid cells. Other than the well-known propensity for leukemia transformation, MPN patients are… read more here.
Keywords: negative myeloproliferative; second cancers; mpn patients; genomic landscape ... See more keywords