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   Articles with "negative pathogens" as a keyword



Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices

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recommendations! Published in 2021 at "Infectious Diseases and Therapy"

DOI: 10.1007/s40121-020-00385-4

Abstract: Introduction The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. Methods… read more here.

Keywords: body infections; gram negative; foreign body; negative pathogens ... See more keywords

Vancomycin Analogue Restores Meropenem Activity against NDM-1 Gram-Negative Pathogens.

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recommendations! Published in 2018 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.8b00011

Abstract: New Delhi metallo-β-lactamase-1 (NDM-1) is the major contributor to the emergence of carbapenem resistance in Gram-negative pathogens (GNPs) and has caused many clinically available β-lactam antibiotics to become obsolete. A clinically approved inhibitor of metallo-β-lactamase… read more here.

Keywords: inhibitor; gram negative; meropenem activity; negative pathogens ... See more keywords

Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering

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recommendations! Published in 2021 at "Chemical Science"

DOI: 10.1039/d1sc02725e

Abstract: The development of new antibiotics is imperative to fight increasing mortality rates connected to infections caused by multidrug-resistant (MDR) bacteria. In this context, Gram-negative pathogens listed in the WHO priority list are particularly problematic. Darobactin… read more here.

Keywords: darobactin biosynthetic; production; darobactin; gram negative ... See more keywords

Simple and Fast Detection of Resistance to Antibiotic Inhibitors of Protein Synthesis in Gram-Negative Pathogens Through Evaluation of Mitomycin C-Induced Cell Elongation.

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recommendations! Published in 2017 at "Microbial Drug Resistance"

DOI: 10.1089/mdr.2017.0028

Abstract: Increasing the resistance of Gram-negative pathogens to antibiotics that inhibit protein synthesis is of great concern. In life-threatening situations, an early detection of antibiotic resistance may improve patient outcome. A rapid assay for the identification… read more here.

Keywords: gram negative; resistance; protein synthesis; negative pathogens ... See more keywords

Antibiotic Resistance Patterns and Association With the Influenza Season in the United States: A Multicenter Evaluation Reveals Surprising Associations Between Influenza Season and Resistance in Gram-Negative Pathogens

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recommendations! Published in 2022 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofac039

Abstract: Abstract Background Viral infections are often treated with empiric antibiotics due to suspected bacterial coinfections, leading to antibiotic overuse. We aimed to describe antibiotic resistance (ABR) trends and their association with the influenza season in… read more here.

Keywords: influenza season; negative pathogens; resistance; gram negative ... See more keywords

Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram‐negative pathogens

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recommendations! Published in 2024 at "Biological Reviews"

DOI: 10.1111/brv.13047

Abstract: For centuries, Gram‐negative pathogens have infected the human population and been responsible for numerous diseases in animals and plants. Despite advancements in therapeutics, Gram‐negative pathogens continue to evolve, with some having developed multi‐drug resistant phenotypes.… read more here.

Keywords: gram negative; secretion systems; host; type iii ... See more keywords

Elucidating the Mechanism of Action of the Gram-Negative-Pathogen-Selective Cyclic Antimicrobial Lipopeptide Brevicidine

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recommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00010-23

Abstract: Due to the accelerated appearance of antimicrobial-resistant (AMR) pathogens in clinical infections, new first-in-class antibiotics, operating via novel modes of action, are desperately needed. Brevicidine, a bacterial nonribosomally produced cyclic lipopeptide, has shown potent and… read more here.

Keywords: negative pathogens; action; activity; brevicidine ... See more keywords

Antibiotic Hybrids: the Next Generation of Agents and Adjuvants against Gram-Negative Pathogens?

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recommendations! Published in 2018 at "Clinical Microbiology Reviews"

DOI: 10.1128/cmr.00077-17

Abstract: SUMMARY The global incidence of drug-resistant Gram-negative bacillary infections has been increasing, and there is a dire need to develop novel strategies to overcome this problem. Intrinsic resistance in Gram-negative bacteria, such as their protective… read more here.

Keywords: hybrids next; gram negative; negative pathogens; agents adjuvants ... See more keywords

Pixantrone Sensitizes Gram-Negative Pathogens to Rifampin

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recommendations! Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.02114-22

Abstract: Bacterial resistance has become increasingly serious because of the widespread use and abuse of antibiotics. In particular, the emergence of multidrug-resistant bacteria has posed a serious threat to human public health. ABSTRACT The emergence of… read more here.

Keywords: negative pathogens; resistance; multidrug resistant; pix ... See more keywords

Detection of Beta-Lactamases (ESBL and MBL) Producing Gram-Negative Pathogens in National Public Health Laboratory of Nepal

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recommendations! Published in 2022 at "International Journal of Microbiology"

DOI: 10.1155/2022/5474388

Abstract: Background Bacterial resistance to antibiotics has increased in recent years. Resistance to β-lactams in Gram-negative bacteria has been reported to be associated with extended spectrum beta-lactamases and metallo-beta-lactamases. This study was aimed at determining the… read more here.

Keywords: negative pathogens; mbl; esbl mbl; beta lactamases ... See more keywords

Potential Application of Cephalosporins Carried in Organic or Inorganic Nanosystems Against Gram-negative Pathogens.

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recommendations! Published in 2022 at "Current medicinal chemistry"

DOI: 10.2174/0929867329666220329201817

Abstract: Cephalosporins are β-lactam antibiotics, classified into five generations and extensively used in clinical practice against infections caused by Gram-negative pathogens, including Enterobacteriaceae and P. aeruginosa. Commercially, conventional pharmaceutical forms require high doses to ensure clinical… read more here.

Keywords: negative pathogens; cephalosporins carried; organic inorganic; potential application ... See more keywords